Literature DB >> 24789984

The brain melanocortin system, sympathetic control, and obesity hypertension.

Alexandre A da Silva1, Jussara M do Carmo, Zhen Wang, John E Hall.   

Abstract

Excess weight gain is the most significant, preventable cause of increased blood pressure (BP) in patients with primary (essential) hypertension and increases the risk for cardiovascular and renal diseases. In this review, we discuss the role of the brain melanocortin system in causing increased sympathetic activity in obesity and other forms of hypertension. In addition, we highlight potential mechanisms by which the brain melanocortin system modulates metabolic and cardiovascular functions.

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Year:  2014        PMID： 24789984      PMCID： PMC4046815          DOI： 10.1152/physiol.00061.2013

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  56 in total

1.  The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist.

Authors:  Gina L C Yosten; Willis K Samson
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2010-03-24       Impact factor: 3.619

Review 2.  Mediators of sympathetic activation in metabolic syndrome obesity.

Authors:  Nora E Straznicky; Nina Eikelis; Elisabeth A Lambert; Murray D Esler
Journal:  Curr Hypertens Rep       Date:  2008-12       Impact factor: 5.369

3.  Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic outflow and blood pressure.

Authors:  Peng Li; Bai-Ping Cui; Ling-Li Zhang; Hai-Jian Sun; Tong-Yan Liu; Guo-Qing Zhu
Journal:  Exp Physiol       Date:  2012-08-07       Impact factor: 2.969

4.  Sympathetic response to insulin is mediated by melanocortin 3/4 receptors in the hypothalamic paraventricular nucleus.

Authors:  Kathryn R Ward; James F Bardgett; Lawrence Wolfgang; Sean D Stocker
Journal:  Hypertension       Date:  2011-01-24       Impact factor: 10.190

5.  Antihypertensive effect of alpha- and beta-adrenergic blockade in obese and lean hypertensive subjects.

Authors:  M R Wofford; D C Anderson; C A Brown; D W Jones; M E Miller; J E Hall
Journal:  Am J Hypertens       Date:  2001-07       Impact factor: 2.689

6.  Systemic but not central nervous system nitric oxide synthase inhibition exacerbates the hypertensive effects of chronic melanocortin-3/4 receptor activation.

Authors:  Jussara M do Carmo; Mirian Bassi; Alexandre A da Silva; John E Hall
Journal:  Hypertension       Date:  2011-01-24       Impact factor: 10.190

7.  Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein.

Authors:  John D Overton; Rudolph L Leibel
Journal:  J Biol Chem       Date:  2011-04-01       Impact factor: 5.157

8.  Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system.

Authors:  Gina L C Yosten; Willis K Samson
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2009-05-27       Impact factor: 3.619

9.  Cardiovascular, renal, and metabolic responses to chronic central administration of agouti-related peptide.

Authors:  Lakshmi S Tallam; Jay J Kuo; Alexandre A da Silva; John E Hall
Journal:  Hypertension       Date:  2004-11-15       Impact factor: 10.190

10.  Gastric bypass surgery is followed by lowered blood pressure and increased diuresis - long term results from the Swedish Obese Subjects (SOS) study.

Authors:  Peter Hallersund; Lars Sjöström; Torsten Olbers; Hans Lönroth; Peter Jacobson; Ville Wallenius; Ingmar Näslund; Lena M Carlsson; Lars Fändriks
Journal:  PLoS One       Date:  2012-11-29       Impact factor: 3.240
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  18 in total

1.  Melanocortin-4 Receptor Deficiency Attenuates Placental Ischemia-Induced Hypertension in Pregnant Rats.

Authors:  Frank T Spradley; Ana C Palei; Christopher D Anderson; Joey P Granger
Journal:  Hypertension       Date:  2019-01       Impact factor: 10.190

Review 2.  Control of respiratory and cardiovascular functions by leptin.

Authors:  M Bassi; W I Furuya; D B Zoccal; J V Menani; E Colombari; J E Hall; A A da Silva; J M do Carmo; D S A Colombari
Journal:  Life Sci       Date:  2015-01-30       Impact factor: 5.037

Review 3.  Melanocortin-4 Receptors and Sympathetic Nervous System Activation in Hypertension.

Authors:  Alexandre A da Silva; Jussara M do Carmo; Zhen Wang; John E Hall
Journal:  Curr Hypertens Rep       Date:  2019-04-26       Impact factor: 5.369

Review 4.  Exercise and Health-Related Risks of Physical Deconditioning After Spinal Cord Injury.

Authors:  Jennifer L Maher; David W McMillan; Mark S Nash
Journal:  Top Spinal Cord Inj Rehabil       Date:  2017

5.  Central role for melanocortin-4 receptors in offspring hypertension arising from maternal obesity.

Authors:  Anne-Maj S Samuelsson; Amandine Mullier; Nuria Maicas; Nynke R Oosterhuis; Sung Eun Bae; Tatiana V Novoselova; Li F Chan; Joaquim M Pombo; Paul D Taylor; Jaap A Joles; Clive W Coen; Nina Balthasar; Lucilla Poston
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-06       Impact factor: 11.205

Review 6.  Role of Hyperinsulinemia and Insulin Resistance in Hypertension: Metabolic Syndrome Revisited.

Authors:  Alexandre A da Silva; Jussara M do Carmo; Xuan Li; Zhen Wang; Alan J Mouton; John E Hall
Journal:  Can J Cardiol       Date:  2020-02-12       Impact factor: 5.223

7.  Differential body weight, blood pressure and placental inflammatory responses to normal versus high-fat diet in melanocortin-4 receptor-deficient pregnant rats.

Authors:  Frank T Spradley; Ana C Palei; Joey P Granger
Journal:  J Hypertens       Date:  2016-10       Impact factor: 4.844

Review 8.  Obesity-Induced Hypertension: Brain Signaling Pathways.

Authors:  Jussara M do Carmo; Alexandre A da Silva; Zhen Wang; Taolin Fang; Nicola Aberdein; Cecilia E P de Lara Rodriguez; John E Hall
Journal:  Curr Hypertens Rep       Date:  2016-07       Impact factor: 5.369

9.  Chronic central nervous system MC3/4R blockade attenuates hypertension induced by nitric oxide synthase inhibition but not by angiotensin II infusion.

Authors:  Alexandre A da Silva; Jussara M do Carmo; John H Dubinion; Mirian Bassi; Kasra Mokhtarpouriani; Shereen M Hamza; John E Hall
Journal:  Hypertension       Date:  2014-10-06       Impact factor: 10.190

10.  Linking Chronic Inflammation with Cardiovascular Disease: From Normal Aging to the Metabolic Syndrome.

Authors:  Angel Lopez-Candales; Paula M Hernández Burgos; Dagmar F Hernandez-Suarez; David Harris
Journal:  J Nat Sci       Date:  2017-04
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