| Literature DB >> 28274841 |
Jussara M do Carmo1, Alexandre A da Silva2, Zhen Wang3, Taolin Fang3, Nicola Aberdein3, Cecilia E Perez de Lara3, John E Hall3.
Abstract
Melanocortins play an important role in regulating blood pressure (BP) and sympathetic nervous system (SNS) activity as well as energy balance, glucose and other metabolic functions in humans and experimental animals. In experimental models of hypertension with high SNS activity, blockade of the melanocortin-4 receptor (MC4R) reduces BP despite causing marked hyperphagia and obesity. Activation of the central nervous system (CNS) pro-opiomelanocortin (POMC)-MC4R pathway appears to be an important link between obesity, SNS activation and hypertension. Despite having severe obesity, subjects with MC4R deficiency exhibit reductions in BP, heart rate, and urinary catecholamine excretion, as well as attenuated SNS responses to cold stimuli compared to obese subjects with normal MC4R function. In this review we discuss the importance of the brain POMC-MC4R system in regulating SNS activity and BP in obesity and other forms of hypertension. We also highlight potential mechanisms and brain circuitry by which the melanocortin system regulates cardiovascular function.Entities:
Keywords: Hypertension; Melanocortin-4 receptor; Obesity; Pro-opiomelanocortin; Sympathetic activity
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Year: 2017 PMID： 28274841 PMCID： PMC5587353 DOI： 10.1016/j.bbadis.2017.03.003
Source DB: PubMed Journal: Biochim Biophys Acta Mol Basis Dis ISSN： 0925-4439 Impact factor: 5.187