BACKGROUND: Reduction of allergen exposure from birth may reduce sensitization and subsequent allergic disease. OBJECTIVE: To measure the influence of mite allergen-impermeable mattress encasings and cotton placebo encasings on the amount of dust and mite allergen in beds. METHODS: A total of 810 children with allergic mothers took part in the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) study. Allergen-impermeable and placebo mattress encasings were applied to the childrens' and the parents' beds before birth. Dust samples were taken from the beds of children and their parents before birth and 3 and 12 months after birth. Extracts of dust samples were analysed for mite allergens (Der p 1 and Der f 1). RESULTS: Active mattress encasings were significantly more effective in reducing dust and mite allergen levels than placebo encasings. Mite allergen levels were low in general and the treatment effect was modest. Twelve months after birth, mattresses with active mattress encasings had about half the amount of Der 1 (Der p 1 + Der f 1)/m2, compared to mattresses with placebo encasings, for the child's and the parental mattress. CONCLUSION: This study shows that mite-impermeable mattress encasings have a significant but modest effect on dust and mite allergen levels of mattresses with low initial mite allergen levels, compared to placebo.
RCT Entities:
BACKGROUND: Reduction of allergen exposure from birth may reduce sensitization and subsequent allergic disease. OBJECTIVE: To measure the influence of mite allergen-impermeable mattress encasings and cotton placebo encasings on the amount of dust and mite allergen in beds. METHODS: A total of 810 children with allergic mothers took part in the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) study. Allergen-impermeable and placebo mattress encasings were applied to the childrens' and the parents' beds before birth. Dust samples were taken from the beds of children and their parents before birth and 3 and 12 months after birth. Extracts of dust samples were analysed for mite allergens (Der p 1 and Der f 1). RESULTS: Active mattress encasings were significantly more effective in reducing dust and mite allergen levels than placebo encasings. Mite allergen levels were low in general and the treatment effect was modest. Twelve months after birth, mattresses with active mattress encasings had about half the amount of Der 1 (Der p 1 + Der f 1)/m2, compared to mattresses with placebo encasings, for the child's and the parental mattress. CONCLUSION: This study shows that mite-impermeable mattress encasings have a significant but modest effect on dust and mite allergen levels of mattresses with low initial mite allergen levels, compared to placebo.
Authors: Esmeralda J M Krop; Gert Doekes; Martin J Stone; Rob C Aalberse; Jaring S van der Zee Journal: Occup Environ Med Date: 2006-10-19 Impact factor: 4.402
Authors: Marjolein P de Vries; Lisette van den Bemt; Karen Aretz; Bart P A Thoonen; Jean W M Muris; Arnold D M Kester; Sonja Cloosterman; C P Onno van Schayck Journal: Br J Gen Pract Date: 2007-03 Impact factor: 5.386
Authors: Diane R Gold; Gary Adamkiewicz; Syed Hasan Arshad; Juan C Celedón; Martin D Chapman; Ginger L Chew; Donald N Cook; Adnan Custovic; Ulrike Gehring; James E Gern; Christine C Johnson; Suzanne Kennedy; Petros Koutrakis; Brian Leaderer; Herman Mitchell; Augusto A Litonjua; Geoffrey A Mueller; George T O'Connor; Dennis Ownby; Wanda Phipatanakul; Victoria Persky; Matthew S Perzanowski; Clare D Ramsey; Päivi M Salo; Julie M Schwaninger; Joanne E Sordillo; Avrum Spira; Shakira F Suglia; Alkis Togias; Darryl C Zeldin; Elizabeth C Matsui Journal: J Allergy Clin Immunol Date: 2017-05-10 Impact factor: 10.793