Literature DB >> 12678756

Naphthalimides as anti-cancer agents: synthesis and biological activity.

M F Braña1, A Ramos.   

Abstract

Naphthalimides are a class of compounds with high antitumor activity upon a variety of murine and human tumor cells. These compounds bind to DNA by intercalation of the chromophore and two of them, mitonafide and amonafide, were used in clinical trials. The therapeutic properties of these lead drugs were improved by designing bisintercalating agents. One of these, elinafide, showed intense in vitro and in vivo activity and is currently being used in clinical trials against solid tumors. In this paper, the history of elinafide is described.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 12678756     DOI： 10.2174/1568011013354624

Source DB:  PubMed          Journal:  Curr Med Chem Anticancer Agents        ISSN： 1568-0118


  36 in total

1.  Synthesis and photophysical characterizations of thermal-stable naphthalene benzimidazoles.

Authors:  Sule Erten-Ela; Serdar Ozcelik; Esin Eren
Journal:  J Fluoresc       Date:  2011-01-29       Impact factor: 2.217

2.  In vitro and in vivo anticancer activity of a novel nano-sized formulation based on self-assembling polymers against pancreatic cancer.

Authors:  Clare Hoskins; Mehdi Ouaissi; Sofia Costa Lima; Woei Ping Cheng; Inês Loureirio; Eric Mas; Dominique Lombardo; Anabela Cordeiro-da-Silva; Ali Ouaissi; Paul Kong Thoo Lin
Journal:  Pharm Res       Date:  2010-09-25       Impact factor: 4.200

3.  A highly Selective Fluorescent Sensor for Monitoring Cu2+ Ion: Synthesis, Characterization and Photophysical Properties.

Authors:  Stephen Opeyemi Aderinto; Yuling Xu; Hongping Peng; Fei Wang; Huilu Wu; Xuyang Fan
Journal:  J Fluoresc       Date:  2016-09-17       Impact factor: 2.217

4.  Phase I trial of UNBS5162, a novel naphthalimide in patients with advanced solid tumors or lymphoma.

Authors:  Daruka Mahadevan; Donald W Northfelt; Pavani Chalasani; Diane Rensvold; Sandra Kurtin; Daniel D Von Hoff; Mitesh J Borad; Raoul Tibes
Journal:  Int J Clin Oncol       Date:  2012-10-11       Impact factor: 3.402

5.  Spectroscopic and quantum mechanical approach of solvatochromic immobilization: modulation of electronic structure and excited-state properties of 1,8-naphthalimide derivative.

Authors:  Soumya Sundar Mati; Sayantani Chall; Soumyadipta Rakshit; Subhash Chandra Bhattacharya
Journal:  J Fluoresc       Date:  2015-02-14       Impact factor: 2.217

6.  Characterization of the cell growth inhibitory effects of a novel DNA-intercalating bipyridyl-thiourea-Pt(II) complex in cisplatin-sensitive and -resistant human ovarian cancer cells.

Authors:  Gaetano Marverti; Alessio Ligabue; Monica Montanari; Davide Guerrieri; Matteo Cusumano; Maria Letizia Di Pietro; Leonarda Troiano; Elena Di Vono; Stefano Iotti; Giovanna Farruggia; Federica Wolf; Maria Giuseppina Monti; Chiara Frassineti
Journal:  Invest New Drugs       Date:  2009-10-16       Impact factor: 3.850

7.  5-Butyl-amino-2-[2-(dimethyl-amino)eth-yl]-1H-benz[de]isoquinoline-1,3(2H)-dione.

Authors:  Li-Juan Xie
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-05-26

8.  2-(4-Amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-ylmeth-yl)isoindoline-1,3-dione.

Authors:  Uzma Yunus; Mohammad Kalim Tahir; Moazzam Hussain Bhatti; Naveeda Yousaf; Madeleine Helliwell
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-01-23

9.  2-(3-Bromo-prop-yl)isoindoline-1,3-dione.

Authors:  Peng-Fei Cheng; Chao-Jie Wang; Yu-Xia Wang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-10-03

Review 10.  Dimeric approaches to anti-cancer chemotherapeutics.

Authors:  M K Hadden; B S J Blagg
Journal:  Anticancer Agents Med Chem       Date:  2008-10       Impact factor: 2.505
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.