| Literature DB >> 12672499 |
Michael R Culbertson1, Peter F Leeds.
Abstract
In eukaryotes, mRNAs are monitored for errors in gene expression by RNA surveillance where untranslatable mRNAs are selectively degraded by the nonsense-mediated mRNA decay (NMD) pathway. Depending on the organism, three to seven genes are required for NMD. Besides RNA surveillance, the genes required for NMD serve a second purpose by controlling the overall abundance of a substantial fraction of the transcriptome.Mesh:
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Year: 2003 PMID: 12672499 DOI: 10.1016/s0959-437x(03)00014-5
Source DB: PubMed Journal: Curr Opin Genet Dev ISSN: 0959-437X Impact factor: 5.578