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Literature DB >> 1266848

Application of the lod method to the detection of linkage between a quantitative trait and a qualitative marker: a simulation experiment.

Abstract

Simulation experiments were performed to assess the power of the lod method for detecting linkage between a quantitative trait and a qualitative marker. Using family data on the Amy2-Duffy linkage, it was found that linkage detection is feasible in certain limited circumstances. The same qualitative data yielded no evidence for a significant difference in male and female recombination fractions.

Entities: Gene

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Year: 1976 PMID： 1266848 PMCID： PMC1684928

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

14 in total

1. The prior probability of autosomal linkage.

Authors: R C Elston; K Lange
Journal: Ann Hum Genet Date: 1975-01 Impact factor: 1.670

2. Quantitative linkage: a statistical procedure for its detection and estimation.

Authors: A P Hill
Journal: Ann Hum Genet Date: 1975-05 Impact factor: 1.670

3. Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors: J Ott
Journal: Am J Hum Genet Date: 1974-09 Impact factor: 11.025

4. Human amylase loci: genetic linkage with the Duffy blood group locus and assignment to linkage group I.

Authors: A D Merritt; E W Lovrien; M L Rivas; P M Conneally
Journal: Am J Hum Genet Date: 1973-09 Impact factor: 11.025

5. Salivary and pancreatic amylase: electrophoretic characterizations and genetic studies.

Authors: A D Merritt; M L Rivas; D Bixler; R Newell
Journal: Am J Hum Genet Date: 1973-09 Impact factor: 11.025

6. Studies on blood and urine glucose in Seminole Indians: indications for segregation of a major gene.

Authors: R C Elston; K K Namboodiri; H V Nino; W S Pollitzer
Journal: Am J Hum Genet Date: 1974-01 Impact factor: 11.025

7. The relation of parental sex and age to recombination in the HL-A system.

Authors: L R Weitkamp; J J Van Rood; E Thorsby; W Bias; M Fotino; S D Lawler; J Dausset; W R Mayr; J Bodmer; F E Ward; J Seignalet; R Payne; F Kissmeyer-Nielsen; R A Gatti; J A Sachs; L U Lamm
Journal: Hum Hered Date: 1973 Impact factor: 0.444

8. The investigation of linkage between a quantitative trait and a marker locus.

Authors: J K Haseman; R C Elston
Journal: Behav Genet Date: 1972-03 Impact factor: 2.805

9. Demonstration of a sex difference in recombination fraction in the loose linkage, Rh and PGM.

Authors: P J Cook; J Noades; D A Hopkinson; E B Robson; T E Cleghorn
Journal: Ann Hum Genet Date: 1972-03 Impact factor: 1.670

10. Study of the genetic transmission of hypercholesterolemia and hypertriglyceridemia in a 195 member kindred.

Authors: R C Elston; K K Namboodiri; C J Glueck; R Fallat; R Tsang; V Leuba
Journal: Ann Hum Genet Date: 1975-07 Impact factor: 1.670

7 in total

1. Comparison of a multipoint identity-by-descent method with parametric multipoint linkage analysis for mapping quantitative traits.

Authors: D E Goldgar; R S Oniki
Journal: Am J Hum Genet Date: 1992-03 Impact factor: 11.025

6. Identifying pedigrees segregating at a major locus for a quantitative trait: an efficient strategy for linkage analysis.

Authors: M Boehnke; P P Moll
Journal: Am J Hum Genet Date: 1989-02 Impact factor: 11.025

7. Waardenburg syndrome (WS): the analysis of a single family with a WS1 mutation showing linkage to RFLP markers on human chromosome 2q.

Authors: J H Asher; R Morell; T B Friedman
Journal: Am J Hum Genet Date: 1991-01 Impact factor: 11.025