Literature DB >> 3463204

Bias of the contribution of single-locus effects to the variance of a quantitative trait.

E Boerwinkle, C F Sing.   

Abstract

Advances in our understanding of the physiology of many quantitative phenotypes combined with better measurement abilities is providing a means for pursuing a measured genotype approach to partitioning the phenotypic variance into the contribution of separate loci. The standard estimate of the contribution of a single locus to the phenotypic variance applied recently in the human genetics literature is a biased statistic. We compare the biased estimates from several published studies with biased corrected estimates to illustrate the general problem.

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Year:  1986        PMID： 3463204      PMCID： PMC1684015     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  14 in total

1.  QUANTITATIVE DIFFERENCES AND GENE DOSAGE IN THE HUMAN RED CELL ACID PHOSPHATASE POLYMORPHISM.

Authors:  N SPENCER; D A HOPKINSON; H HARRIS
Journal:  Nature       Date:  1964-01-18       Impact factor: 49.962

2.  The genetic determination of plasma apolipoprotein A-I levels measured by radioimmunoassay: a study of high-risk pedigrees.

Authors:  P P Moll; C F Sing; R R Williams; S J Mao; B A Kottke
Journal:  Am J Hum Genet       Date:  1986-03       Impact factor: 11.025

3.  The use of measured genotype information in the analysis of quantitative phenotypes in man. I. Models and analytical methods.

Authors:  E Boerwinkle; R Chakraborty; C F Sing
Journal:  Ann Hum Genet       Date:  1986-05       Impact factor: 1.670

4.  Common polymorphism of peptidase A. Electrohoretic variants associated with quantitative variation of red cell levels.

Authors:  W H Lewis
Journal:  Ann Hum Genet       Date:  1973-01       Impact factor: 1.670

5.  The use of biochemical data in screening for mutant alleles and in genetic counselling.

Authors:  R J Gold; U R Maag; J L Neal; C R Scriver
Journal:  Ann Hum Genet       Date:  1974-01       Impact factor: 1.670

6.  Studies on blood and urine glucose in Seminole Indians: indications for segregation of a major gene.

Authors:  R C Elston; K K Namboodiri; H V Nino; W S Pollitzer
Journal:  Am J Hum Genet       Date:  1974-01       Impact factor: 11.025

7.  Genetic regulation of plasma and red blood cell magnesium concentration in man. II. Segregation analysis.

Authors:  J M Lalouel; P Darlu; J G Henrotte; D C Rao
Journal:  Am J Hum Genet       Date:  1983-09       Impact factor: 11.025

8.  Apolipoprotein E polymorphism and coronary artery disease.

Authors:  H J Menzel; R G Kladetzky; G Assmann
Journal:  Arteriosclerosis       Date:  1983 Jul-Aug

9.  Genetic analysis of systolic blood pressure in Melbourne families.

Authors:  J L Hopper; B D Tait; D N Propert; J D Mathews
Journal:  Clin Exp Pharmacol Physiol       Date:  1982 May-Jun       Impact factor: 2.557

10.  Heritability of quantitative variation at the group-specific component (Gc) locus.

Authors:  S P Daiger; M Miller; R Chakraborty
Journal:  Am J Hum Genet       Date:  1984-05       Impact factor: 11.025
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  18 in total

1.  A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation.

Authors:  M R Nelson; S L Kardia; R E Ferrell; C F Sing
Journal:  Genome Res       Date:  2001-03       Impact factor: 9.043

2.  Genetic variance for body size in a natural population of Drosophila buzzatii.

Authors:  A Ruiz; M Santos; A Barbadilla; J E Quezada-Díaz; E Hasson; A Fontdevila
Journal:  Genetics       Date:  1991-08       Impact factor: 4.562

3.  Genotype-environment interaction: apolipoprotein E (ApoE) gene effects and age as an index of time and spatial context in the human.

Authors:  K E Zerba; R E Ferrell; C F Sing
Journal:  Genetics       Date:  1996-05       Impact factor: 4.562

4.  Simultaneous effects of the apolipoprotein E polymorphism on apolipoprotein E, apolipoprotein B, and cholesterol metabolism.

Authors:  E Boerwinkle; G Utermann
Journal:  Am J Hum Genet       Date:  1988-01       Impact factor: 11.025

5.  The contribution of quantitative trait loci and neutral marker loci to the genetic variances and covariances among quantitative traits in random mating populations.

Authors:  A Ruiz; A Barbadilla
Journal:  Genetics       Date:  1995-01       Impact factor: 4.562

6.  Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolism.

Authors:  Jari H Stengård; Andrew G Clark; Kenneth M Weiss; Sharon Kardia; Deborah A Nickerson; Veikko Salomaa; Christian Ehnholm; Eric Boerwinkle; Charles F Sing
Journal:  Am J Hum Genet       Date:  2002-08-05       Impact factor: 11.025

7.  ATHENA: A knowledge-based hybrid backpropagation-grammatical evolution neural network algorithm for discovering epistasis among quantitative trait Loci.

Authors:  Stephen D Turner; Scott M Dudek; Marylyn D Ritchie
Journal:  BioData Min       Date:  2010-09-27       Impact factor: 2.522

8.  A common genetic mechanism determines plasma apolipoprotein B levels and dense LDL subfraction distribution in familial combined hyperlipidemia.

Authors:  S H Juo; S J Bredie; L A Kiemeney; P N Demacker; A F Stalenhoef
Journal:  Am J Hum Genet       Date:  1998-08       Impact factor: 11.025

9.  Human apolipoprotein A-IV polymorphism: frequency and effect on lipid and lipoprotein levels.

Authors:  H J Menzel; E Boerwinkle; S Schrangl-Will; G Utermann
Journal:  Hum Genet       Date:  1988-08       Impact factor: 4.132

10.  Tree scanning: a method for using haplotype trees in phenotype/genotype association studies.

Authors:  Alan R Templeton; Taylor Maxwell; David Posada; Jari H Stengård; Eric Boerwinkle; Charles F Sing
Journal:  Genetics       Date:  2004-09-15       Impact factor: 4.562
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