| Literature DB >> 12657279 |
Ping Chen1, Derek Norris, Kristin D Haslow, T G Murali Dhar, William J Pitts, Scott H Watterson, Daniel L Cheney, Donna A Bassolino, Catherine A Fleener, Katherine A Rouleau, Diane L Hollenbaugh, Robert M Townsend, Joel C Barrish, Edwin J Iwanowicz.
Abstract
Screening of our in-house compound collection led to the discovery of 5-bromo-6-amino-2-isoquinoline 1 as a weak inhibitor of IMPDH. Subsequent optimization of 1 afforded a series of novel 2-isoquinolinoaminooxazole-based inhibitors, represented by 17, with single-digit nanomolar potency against the enzyme.Entities:
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Year: 2003 PMID： 12657279 DOI： 10.1016/s0960-894x(03)00107-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823