Literature DB >> 12654774

Interleukin-18 impairs the pulmonary host response to Pseudomonas aeruginosa.

Marc J Schultz1, Sylvia Knapp, Sandrine Florquin, Jennie Pater, Kiyoshi Takeda, Shizuo Akira, Tom van der Poll.   

Abstract

Interleukin-18 (IL-18) is a potent cytokine with many different proinflammatory activities. To study the role of IL-18 in the pathogenesis of Pseudomonas pneumonia, IL-18-deficient (IL-18(-/-)) and wild-type mice were intranasally inoculated with Pseudomonas aeruginosa. IL-18 deficiency was associated with reduced outgrowth of Pseudomonas in the lungs and diminished dissemination of the infection. In addition, pulmonary inflammation (histopathology) and levels of tumor necrosis factor alpha, IL-6, and macrophage inflammatory protein-2 in lungs and plasma were lower in IL-18(-/-) mice. Consistent with results obtained for IL-18(-/-) mice, treatment of wild-type mice with a neutralizing IL-18 binding protein-immunoglobulin G Fc fusion construct also attenuated outgrowth of Pseudomonas compared with that for mice treated with a control protein. These results demonstrate that the presence of endogenous IL-18 activity facilitates inflammatory responses in the lung during Pseudomonas pneumonia, concurrently impairing bacterial clearance.

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Year:  2003        PMID： 12654774      PMCID： PMC152024          DOI： 10.1128/IAI.71.4.1630-1634.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  37 in total

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Authors:  T van der Poll; C V Keogh; W A Buurman; S F Lowry
Journal:  Am J Respir Crit Care Med       Date:  1997-02       Impact factor: 21.405

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Authors:  T van der Poll; A Marchant; C V Keogh; M Goldman; S F Lowry
Journal:  J Infect Dis       Date:  1996-11       Impact factor: 5.226

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Journal:  Eur J Immunol       Date:  1996-07       Impact factor: 5.532

4.  Elevated plasma concentrations of interferon (IFN)-gamma and the IFN-gamma-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis.

Authors:  F N Lauw; A J Simpson; J M Prins; M D Smith; M Kurimoto; S J van Deventer; P Speelman; W Chaowagul; N J White; T van der Poll
Journal:  J Infect Dis       Date:  1999-12       Impact factor: 5.226

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Journal:  Science       Date:  1997-01-10       Impact factor: 47.728

6.  IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12.

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Journal:  J Immunol       Date:  1997-02-15       Impact factor: 5.422

7.  Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production.

Authors:  T Ghayur; S Banerjee; M Hugunin; D Butler; L Herzog; A Carter; L Quintal; L Sekut; R Talanian; M Paskind; W Wong; R Kamen; D Tracey; H Allen
Journal:  Nature       Date:  1997-04-10       Impact factor: 49.962

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Journal:  J Immunol       Date:  1996-06-01       Impact factor: 5.422

9.  Tumor necrosis factor mediates lung antibacterial host defense in murine Klebsiella pneumonia.

Authors:  L L Laichalk; S L Kunkel; R M Strieter; J M Danforth; M B Bailie; T J Standiford
Journal:  Infect Immun       Date:  1996-12       Impact factor: 3.441

10.  Cloning of a new cytokine that induces IFN-gamma production by T cells.

Authors:  H Okamura; H Tsutsi; T Komatsu; M Yutsudo; A Hakura; T Tanimoto; K Torigoe; T Okura; Y Nukada; K Hattori
Journal:  Nature       Date:  1995-11-02       Impact factor: 49.962
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  27 in total

1.  In vivo discrimination of type 3 secretion system-positive and -negative Pseudomonas aeruginosa via a caspase-1-dependent pathway.

Authors:  Tamding Wangdi; Lilia A Mijares; Barbara I Kazmierczak
Journal:  Infect Immun       Date:  2010-09-07       Impact factor: 3.441

Review 2.  Mechanisms and Targeted Therapies for Pseudomonas aeruginosa Lung Infection.

Authors:  Colleen S Curran; Thomas Bolig; Parizad Torabi-Parizi
Journal:  Am J Respir Crit Care Med       Date:  2018-03-15       Impact factor: 21.405

3.  ASC acts in a caspase-1-independent manner to worsen acute pneumonia caused by Pseudomonas aeruginosa.

Authors:  A J Hughes; C A Knoten; A R Morris; A R Hauser
Journal:  J Med Microbiol       Date:  2018-06-29       Impact factor: 2.472

4.  Secretion of Flagellar Proteins by the Pseudomonas aeruginosa Type III Secretion-Injectisome System.

Authors:  Dilek Ince; Fayyaz S Sutterwala; Timothy L Yahr
Journal:  J Bacteriol       Date:  2015-04-06       Impact factor: 3.490

5.  Pseudomonas aeruginosa Triggers Macrophage Autophagy To Escape Intracellular Killing by Activation of the NLRP3 Inflammasome.

Authors:  Qiuchan Deng; Yi Wang; Yuanqing Zhang; Meiyu Li; Dandan Li; Xi Huang; Yongjian Wu; Jieying Pu; Minhao Wu
Journal:  Infect Immun       Date:  2015-10-14       Impact factor: 3.441

6.  Blockade of equilibrative nucleoside transporter 1/2 protects against Pseudomonas aeruginosa-induced acute lung injury and NLRP3 inflammasome activation.

Authors:  Eboni D Chambers; Alexis White; Alexander Vang; Zhengke Wang; Alfred Ayala; Tingting Weng; Michael Blackburn; Gaurav Choudhary; Sharon Rounds; Qing Lu
Journal:  FASEB J       Date:  2019-12-02       Impact factor: 5.191

7.  An essential role for non-bone marrow-derived cells in control of Pseudomonas aeruginosa pneumonia.

Authors:  Adeline M Hajjar; Heidi Harowicz; H Denny Liggitt; Pamela J Fink; Christopher B Wilson; Shawn J Skerrett
Journal:  Am J Respir Cell Mol Biol       Date:  2005-08-11       Impact factor: 6.914

8.  Limited role for interleukin-18 in the host protection response to pulmonary infection with Pseudomonas aeruginosa in mice.

Authors:  Chikara Nakasone; Kazuyoshi Kawakami; Tomoaki Hoshino; Yusuke Kawase; Koichi Yokota; Kohichiro Yoshino; Kiyoshi Takeda; Shizuo Akira; Atsushi Saito
Journal:  Infect Immun       Date:  2004-10       Impact factor: 3.441

9.  Interleukin 18 participates in the early inflammatory response and bacterial clearance during pneumonia caused by nontypeable Haemophilus influenzae.

Authors:  Catharina W Wieland; Sandrine Florquin; Tom van der Poll
Journal:  Infect Immun       Date:  2007-07-30       Impact factor: 3.441

10.  Intestinal colonization with Enterococcus faecium does not influence pulmonary defense against Pseudomonas aeruginosa in mice.

Authors:  Masja Leendertse; Rob J L Willems; Ida A J Giebelen; Joris J T H Roelofs; Janetta Top; Marc J M Bonten; Tom van der Poll
Journal:  PLoS One       Date:  2009-08-27       Impact factor: 3.240
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