| Literature DB >> 8999548 |
Y Gu1, K Kuida, H Tsutsui, G Ku, K Hsiao, M A Fleming, N Hayashi, K Higashino, H Okamura, K Nakanishi, M Kurimoto, T Tanimoto, R A Flavell, V Sato, M W Harding, D J Livingston, M S Su.
Abstract
The interleukin-1beta (IL-1beta) converting enzyme (ICE) processes the inactive IL-1beta precursor to the proinflammatory cytokine. ICE was also shown to cleave the precursor of interferon-gamma inducing factor (IGIF) at the authentic processing site with high efficiency, thereby activating IGIF and facilitating its export. Lipopolysaccharide-activated ICE-deficient (ICE-/-) Kupffer cells synthesized the IGIF precursor but failed to process it into the active form. Interferon-gamma and IGIF were diminished in the sera of ICE-/- mice exposed to Propionibacterium acnes and lipopolysaccharide. The lack of multiple proinflammatory cytokines in ICE-/- mice may account for their protection from septic shock.Entities:
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Year: 1997 PMID： 8999548 DOI： 10.1126/science.275.5297.206
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728