Literature DB >> 15385528

Limited role for interleukin-18 in the host protection response to pulmonary infection with Pseudomonas aeruginosa in mice.

Chikara Nakasone1, Kazuyoshi Kawakami, Tomoaki Hoshino, Yusuke Kawase, Koichi Yokota, Kohichiro Yoshino, Kiyoshi Takeda, Shizuo Akira, Atsushi Saito.   

Abstract

We report that clearance of Pseudomonas aeruginosa, accumulation of neutrophils, and synthesis of tumor necrosis factor alpha and macrophage inflammatory protein 2 in the infected lung were not largely different in interleukin-18 (IL-18) knockout or transgenic mice compared with control mice. Our results suggest a limited role for IL-18 in the host defense against P. aeruginosa.

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Year:  2004        PMID： 15385528      PMCID： PMC517573          DOI： 10.1128/IAI.72.10.6176-6180.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  22 in total

Review 1.  The biology of chemokines and their receptors.

Authors:  D Rossi; A Zlotnik
Journal:  Annu Rev Immunol       Date:  2000       Impact factor: 28.527

2.  A role for IL-18 in neutrophil activation.

Authors:  B P Leung; S Culshaw; J A Gracie; D Hunter; C A Canetti; C Campbell; F Cunha; F Y Liew; I B McInnes
Journal:  J Immunol       Date:  2001-09-01       Impact factor: 5.422

Review 3.  Molecular mechanisms of neutrophil recruitment elicited by bacteria in the lungs.

Authors:  Joseph P Mizgerd
Journal:  Semin Immunol       Date:  2002-04       Impact factor: 11.130

4.  IL-18 improves the early antimicrobial host response to pneumococcal pneumonia.

Authors:  Fanny N Lauw; Judith Branger; Sandrine Florquin; Peter Speelman; Sander J H van Deventer; Shizuo Akira; Tom van der Poll
Journal:  J Immunol       Date:  2002-01-01       Impact factor: 5.422

Review 5.  IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family.

Authors:  C A Dinarello
Journal:  J Allergy Clin Immunol       Date:  1999-01       Impact factor: 10.793

6.  CXC chemokine receptor CXCR2 is essential for protective innate host response in murine Pseudomonas aeruginosa pneumonia.

Authors:  W C Tsai; R M Strieter; B Mehrad; M W Newstead; X Zeng; T J Standiford
Journal:  Infect Immun       Date:  2000-07       Impact factor: 3.441

7.  Cutting edge: IL-18-transgenic mice: in vivo evidence of a broad role for IL-18 in modulating immune function.

Authors:  T Hoshino; Y Kawase; M Okamoto; K Yokota; K Yoshino; K Yamamura ; J Miyazaki ; H A Young; K Oizumi
Journal:  J Immunol       Date:  2001-06-15       Impact factor: 5.422

8.  Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia.

Authors:  M G Netea; G Fantuzzi; B J Kullberg; R J Stuyt; E J Pulido; R C McIntyre; L A Joosten; J W Van der Meer; C A Dinarello
Journal:  J Immunol       Date:  2000-03-01       Impact factor: 5.422

9.  IL-18 contributes to host resistance against infection with Pseudomonas aeruginosa through induction of IFN-gamma production.

Authors:  Xi Huang; Sharon A McClellan; Ronald P Barrett; Linda D Hazlett
Journal:  J Immunol       Date:  2002-06-01       Impact factor: 5.422

10.  Interleukin-18 impairs the pulmonary host response to Pseudomonas aeruginosa.

Authors:  Marc J Schultz; Sylvia Knapp; Sandrine Florquin; Jennie Pater; Kiyoshi Takeda; Shizuo Akira; Tom van der Poll
Journal:  Infect Immun       Date:  2003-04       Impact factor: 3.441
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  2 in total

1.  In vivo discrimination of type 3 secretion system-positive and -negative Pseudomonas aeruginosa via a caspase-1-dependent pathway.

Authors:  Tamding Wangdi; Lilia A Mijares; Barbara I Kazmierczak
Journal:  Infect Immun       Date:  2010-09-07       Impact factor: 3.441

2.  Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria.

Authors:  Vincent Feuillet; Samir Medjane; Isabelle Mondor; Olivier Demaria; Philippe P Pagni; Jorge E Galán; Richard A Flavell; Lena Alexopoulou
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-04       Impact factor: 11.205
  2 in total

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