| Literature DB >> 12654738 |
Yuji Morita1, Takeshi Murata, Takehiko Mima, Sumiko Shiota, Teruo Kuroda, Tohru Mizushima, Naomasa Gotoh, Takeshi Nishino, Tomofusa Tsuchiya.
Abstract
Induction of the MexCD-OprJ multidrug efflux pump was investigated in wild-type Pseudomonas aeruginosa PAO1. MexCD-OprJ was induced by clinically important disinfectants such as benzalkonium chloride and chlorhexidine gluconate, and by some cytotoxic agents such as tetraphenylphosphonium chloride, ethidium bromide and rhodamine 6G. MexCD-OprJ was not induced by norfloxacin, tetracycline, chloramphenicol, streptomycin, erythromycin or carbenicillin, although they are substrates for the pump. Cells of PAO1 showed increased resistance to norfloxacin when grown in the presence of the inducers of the mexCD-oprJ operon mentioned above. These results indicate that MexCD-OprJ plays an important role in intrinsic multidrug resistance in wild-type P. aeruginosa in hospitals where disinfectants are used frequently.Entities:
Mesh：
Substances：
Year: 2003 PMID： 12654738 DOI： 10.1093/jac/dkg173
Source DB: PubMed Journal: J Antimicrob Chemother ISSN： 0305-7453 Impact factor: 5.790