Literature DB >> 18838593

MexCD-OprJ multidrug efflux system of Pseudomonas aeruginosa: involvement in chlorhexidine resistance and induction by membrane-damaging agents dependent upon the AlgU stress response sigma factor.

Sebastien Fraud1, Aaron J Campigotto, Zhilin Chen, Keith Poole.   

Abstract

The biocide chlorhexidine (CHX) as well as additional membrane-active agents were shown to induce expression of the mexCD-oprJ multidrug efflux operon, dependent upon the AlgU stress response sigma factor. Hyperexpression of this efflux system in nfxB mutants was also substantially AlgU dependent. CHX resistance correlated with efflux gene expression in various mutants, consistent with MexCD-OprJ being a determinant of CHX resistance.

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Year:  2008        PMID： 18838593      PMCID： PMC2592872          DOI： 10.1128/AAC.01072-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  47 in total

Review 1.  Solubilization of membranes by detergents.

Authors:  A Helenius; K Simons
Journal:  Biochim Biophys Acta       Date:  1975-03-25

2.  Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment.

Authors:  Robert E. W. Hancock; David P. Speert
Journal:  Drug Resist Updat       Date:  2000-08       Impact factor: 18.500

3.  Multidrug efflux pumps: expression patterns and contribution to antibiotic resistance in Pseudomonas aeruginosa biofilms.

Authors:  T R De Kievit; M D Parkins; R J Gillis; R Srikumar; H Ceri; K Poole; B H Iglewski; D G Storey
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

Review 4.  Sensing external stress: watchdogs of the Escherichia coli cell envelope.

Authors:  Natividad Ruiz; Thomas J Silhavy
Journal:  Curr Opin Microbiol       Date:  2005-04       Impact factor: 7.934

Review 5.  Efflux-mediated antimicrobial resistance.

Authors:  Keith Poole
Journal:  J Antimicrob Chemother       Date:  2005-05-24       Impact factor: 5.790

Review 6.  Pushing the envelope: extracytoplasmic stress responses in bacterial pathogens.

Authors:  Gary Rowley; Michael Spector; Jan Kormanec; Mark Roberts
Journal:  Nat Rev Microbiol       Date:  2006-05       Impact factor: 60.633

7.  Characterization of a locus determining the mucoid status of Pseudomonas aeruginosa: AlgU shows sequence similarities with a Bacillus sigma factor.

Authors:  D W Martin; B W Holloway; V Deretic
Journal:  J Bacteriol       Date:  1993-02       Impact factor: 3.490

8.  Functional equivalence of Escherichia coli sigma E and Pseudomonas aeruginosa AlgU: E. coli rpoE restores mucoidy and reduces sensitivity to reactive oxygen intermediates in algU mutants of P. aeruginosa.

Authors:  H Yu; M J Schurr; V Deretic
Journal:  J Bacteriol       Date:  1995-06       Impact factor: 3.490

9.  A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants.

Authors:  T T Hoang; R R Karkhoff-Schweizer; A J Kutchma; H P Schweizer
Journal:  Gene       Date:  1998-05-28       Impact factor: 3.688

10.  Purification of a 54-kilodalton protein (OprJ) produced in NfxB mutants of Pseudomonas aeruginosa and production of a monoclonal antibody specific to OprJ.

Authors:  M Hosaka; N Gotoh; T Nishino
Journal:  Antimicrob Agents Chemother       Date:  1995-08       Impact factor: 5.191
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  46 in total

1.  mexEF-oprN multidrug efflux operon of Pseudomonas aeruginosa: regulation by the MexT activator in response to nitrosative stress and chloramphenicol.

Authors:  Hossam Fetar; Christie Gilmour; Rachael Klinoski; Denis M Daigle; Charles R Dean; Keith Poole
Journal:  Antimicrob Agents Chemother       Date:  2010-11-15       Impact factor: 5.191

Review 2.  Regulation of antimicrobial resistance by extracytoplasmic function (ECF) sigma factors.

Authors:  Emily C Woods; Shonna M McBride
Journal:  Microbes Infect       Date:  2017-01-30       Impact factor: 2.700

Review 3.  Efflux-mediated drug resistance in bacteria: an update.

Authors:  Xian-Zhi Li; Hiroshi Nikaido
Journal:  Drugs       Date:  2009-08-20       Impact factor: 9.546

4.  Molecular mechanisms of chlorhexidine tolerance in Burkholderia cenocepacia biofilms.

Authors:  Tom Coenye; Heleen Van Acker; Elke Peeters; Andrea Sass; Silvia Buroni; Giovanna Riccardi; Eshwar Mahenthiralingam
Journal:  Antimicrob Agents Chemother       Date:  2011-02-28       Impact factor: 5.191

5.  Efflux as a glutaraldehyde resistance mechanism in Pseudomonas fluorescens and Pseudomonas aeruginosa biofilms.

Authors:  Amit Vikram; Jennifer M Bomberger; Kyle J Bibby
Journal:  Antimicrob Agents Chemother       Date:  2015-03-30       Impact factor: 5.191

Review 6.  The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Authors:  Xian-Zhi Li; Patrick Plésiat; Hiroshi Nikaido
Journal:  Clin Microbiol Rev       Date:  2015-04       Impact factor: 26.132

Review 7.  Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.

Authors:  Lucía Fernández; Robert E W Hancock
Journal:  Clin Microbiol Rev       Date:  2012-10       Impact factor: 26.132

8.  Determinants of Antibacterial Spectrum and Resistance Potential of the Elongation Factor G Inhibitor Argyrin B in Key Gram-Negative Pathogens.

Authors:  Adriana K Jones; Angela L Woods; Kenneth T Takeoka; Xiaoyu Shen; Jun-Rong Wei; Ruth E Caughlan; Charles R Dean
Journal:  Antimicrob Agents Chemother       Date:  2017-03-24       Impact factor: 5.191

9.  The SmeYZ efflux pump of Stenotrophomonas maltophilia contributes to drug resistance, virulence-related characteristics, and virulence in mice.

Authors:  Yi-Tsung Lin; Yi-Wei Huang; Shiang-Jiuun Chen; Chia-Wei Chang; Tsuey-Ching Yang
Journal:  Antimicrob Agents Chemother       Date:  2015-04-27       Impact factor: 5.191

Review 10.  The Evolutionary Conservation of Escherichia coli Drug Efflux Pumps Supports Physiological Functions.

Authors:  Tanisha Teelucksingh; Laura K Thompson; Georgina Cox
Journal:  J Bacteriol       Date:  2020-10-22       Impact factor: 3.490
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