Literature DB >> 12937010

Functional cloning and characterization of a multidrug efflux pump, mexHI-opmD, from a Pseudomonas aeruginosa mutant.

Hiroshi Sekiya1, Takehiko Mima, Yuji Morita, Teruo Kuroda, Tohru Mizushima, Tomofusa Tsuchiya.   

Abstract

We isolated mutant YM644, which showed elevated resistance to norfloxacin, ethidium bromide, acriflavine, and rhodamine 6G, from Pseudomonas aeruginosa YM64, a strain that lacks four major multidrug efflux pumps. The genes responsible for the resistance were mexHI-opmD. Elevated ethidium extrusion was observed with cells of YM644 and YM64 harboring a plasmid carrying the genes. Disruption of the genes in the chromosomal DNA of YM644 made the cells sensitive to the drugs.

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Year:  2003        PMID： 12937010      PMCID： PMC182609          DOI： 10.1128/AAC.47.9.2990-2992.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

1.  Construction of a series of mutants lacking all of the four major mex operons for multidrug efflux pumps or possessing each one of the operons from Pseudomonas aeruginosa PAO1: MexCD-OprJ is an inducible pump.

Authors:  Y Morita; Y Komori; T Mima; T Kuroda; T Mizushima; T Tsuchiya
Journal:  FEMS Microbiol Lett       Date:  2001-08-07       Impact factor: 2.742

2.  The multidrug efflux protein NorM is a prototype of a new family of transporters.

Authors:  M H Brown; I T Paulsen; R A Skurray
Journal:  Mol Microbiol       Date:  1999-01       Impact factor: 3.501

Review 3.  Drug efflux proteins in multidrug resistant bacteria.

Authors:  H W van Veen; W N Konings
Journal:  Biol Chem       Date:  1997-08       Impact factor: 3.915

Review 4.  Mechanisms of multidrug transporters.

Authors:  H Bolhuis; H W van Veen; B Poolman; A J Driessen; W N Konings
Journal:  FEMS Microbiol Rev       Date:  1997-08       Impact factor: 16.408

5.  Contribution of the MexX-MexY-oprM efflux system to intrinsic resistance in Pseudomonas aeruginosa.

Authors:  N Masuda; E Sakagawa; S Ohya; N Gotoh; H Tsujimoto; T Nishino
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

6.  Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.

Authors:  C K Stover; X Q Pham; A L Erwin; S D Mizoguchi; P Warrener; M J Hickey; F S Brinkman; W O Hufnagle; D J Kowalik; M Lagrou; R L Garber; L Goltry; E Tolentino; S Westbrock-Wadman; Y Yuan; L L Brody; S N Coulter; K R Folger; A Kas; K Larbig; R Lim; K Smith; D Spencer; G K Wong; Z Wu; I T Paulsen; J Reizer; M H Saier; R E Hancock; S Lory; M V Olson
Journal:  Nature       Date:  2000-08-31       Impact factor: 49.962

7.  Replacement of a phosphoenolpyruvate-dependent phosphotransferase by a nicotinamide adenine dinucleotide-linked dehydrogenase for the utilization of mannitol.

Authors:  S Tanaka; S A Lerner; E C Lin
Journal:  J Bacteriol       Date:  1967-02       Impact factor: 3.490

8.  Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon.

Authors:  K Poole; K Krebes; C McNally; S Neshat
Journal:  J Bacteriol       Date:  1993-11       Impact factor: 3.490

9.  Construction of improved Escherichia-Pseudomonas shuttle vectors derived from pUC18/19 and sequence of the region required for their replication in Pseudomonas aeruginosa.

Authors:  S E West; H P Schweizer; C Dall; A K Sample; L J Runyen-Janecky
Journal:  Gene       Date:  1994-10-11       Impact factor: 3.688

10.  A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants.

Authors:  T T Hoang; R R Karkhoff-Schweizer; A J Kutchma; H P Schweizer
Journal:  Gene       Date:  1998-05-28       Impact factor: 3.688
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  31 in total

1.  The Pseudomonas aeruginosa efflux pump MexGHI-OpmD transports a natural phenazine that controls gene expression and biofilm development.

Authors:  Hassan Sakhtah; Leslie Koyama; Yihan Zhang; Diana K Morales; Blanche L Fields; Alexa Price-Whelan; Deborah A Hogan; Kenneth Shepard; Lars E P Dietrich
Journal:  Proc Natl Acad Sci U S A       Date:  2016-06-06       Impact factor: 11.205

Review 2.  Xenobiotic efflux in bacteria and fungi: a genomics update.

Authors:  Ravi D Barabote; Jose Thekkiniath; Richard E Strauss; Govindsamy Vediyappan; Joe A Fralick; Michael J San Francisco
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  2011

3.  Global reprogramming of virulence and antibiotic resistance in Pseudomonas aeruginosa by a single nucleotide polymorphism in elongation factor, fusA1.

Authors:  Eve A Maunders; Rory C Triniman; Joshua Western; Taufiq Rahman; Martin Welch
Journal:  J Biol Chem       Date:  2020-09-17       Impact factor: 5.157

4.  Role of the MexEF-OprN efflux system in low-level resistance of Pseudomonas aeruginosa to ciprofloxacin.

Authors:  Catherine Llanes; Thilo Köhler; Isabelle Patry; Barbara Dehecq; Christian van Delden; Patrick Plésiat
Journal:  Antimicrob Agents Chemother       Date:  2011-09-12       Impact factor: 5.191

5.  Inactivation of MuxABC-OpmB transporter system in Pseudomonas aeruginosa leads to increased ampicillin and carbenicillin resistance and decreased virulence.

Authors:  Liang Yang; Lin Chen; Lixin Shen; Michael Surette; Kangmin Duan
Journal:  J Microbiol       Date:  2011-03-03       Impact factor: 3.422

6.  Pseudomonas aeruginosa SoxR does not conform to the archetypal paradigm for SoxR-dependent regulation of the bacterial oxidative stress adaptive response.

Authors:  Marco Palma; Juan Zurita; Julian A Ferreras; Stefan Worgall; Davise H Larone; Lei Shi; Fabien Campagne; Luis E N Quadri
Journal:  Infect Immun       Date:  2005-05       Impact factor: 3.441

7.  Influence of quorum sensing and iron on twitching motility and biofilm formation in Pseudomonas aeruginosa.

Authors:  Glenn M Patriquin; Ehud Banin; Christie Gilmour; Rivka Tuchman; E Peter Greenberg; Keith Poole
Journal:  J Bacteriol       Date:  2007-11-09       Impact factor: 3.490

8.  Differential impact of MexB mutations on substrate selectivity of the MexAB-OprM multidrug efflux pump of Pseudomonas aeruginosa.

Authors:  Jocelyn K Middlemiss; Keith Poole
Journal:  J Bacteriol       Date:  2004-03       Impact factor: 3.490

9.  Kinetic Control of Quorum Sensing in Pseudomonas aeruginosa by Multidrug Efflux Pumps.

Authors:  David Wolloscheck; Ganesh Krishnamoorthy; Jennifer Nguyen; Helen I Zgurskaya
Journal:  ACS Infect Dis       Date:  2017-11-10       Impact factor: 5.084

10.  An H(+)-coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosa.

Authors:  Gui-Xin He; Teruo Kuroda; Takehiko Mima; Yuji Morita; Tohru Mizushima; Tomofusa Tsuchiya
Journal:  J Bacteriol       Date:  2004-01       Impact factor: 3.490
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