| Literature DB >> 12652301 |
David E Reich1, Stacey B Gabriel, David Altshuler.
Abstract
To address the quality and completeness of single-nucleotide polymorphism (SNP) databases, we resequenced 173 kb (spanning 17 loci) in 150 chromosomes of west African and European ancestry. Over 88% of SNPs in the public (TSC and BAC overlap) and Celera databases were confirmed in independent resequencing. Approximately 45% of all human heterozygosity is attributable to SNPs already available from the two databases, and of SNPs with minor-allele frequencies >10%, more than half are represented.Entities:
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Year: 2003 PMID： 12652301 DOI： 10.1038/ng1133
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330