| Literature DB >> 12646020 |
Deborah H Slee1, Abhijit S Bhat, Truc N Nguyen, Mary Kish, Katy Lundeen, Michael J Newman, Stephen J McConnell.
Abstract
The regulation of lipid metabolism and it's effect on glucose control and diabetes has received intense interest. Hormone-sensitive lipase (HSL) is a vital enzyme in lipid metabolism. A series of novel pyrrolopyrazinediones has been discovered that demonstrate submicromolar activity both in the enzyme assay and in a (14)C-emulsion assay employing cholesteryl oleate as a substrate as a secondary measure of HSL activity. These compounds represent novel inhibitors of the human HSL enzyme.Entities:
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Year: 2003 PMID： 12646020 DOI： 10.1021/jm020460y
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446