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Literature DB >> 17464371

Microwave-Enhanced High-Speed Fluorous Synthesis.

Abstract

Increasing reaction speed and simplifying product purification are two major ways to improve the efficiency of organic synthesis. A new technology for high-speed solution-phase synthesis has been developed by combination of microwave heating and fluorous purification. This review describes different techniques for microwave-enhanced fluorous synthesis and their applications in Pd-catalyzed cross-coupling reactions, free-radical reactions, multicomponent reactions, and compound library synthesis.

Entities: Chemical

Year: 2006 PMID： 17464371 PMCID： PMC1857347 DOI： 10.1007/128_045

Source DB: PubMed Journal: Top Curr Chem ISSN： 0340-1022

27 in total

Review 1. Perspective Articles on the utility and application of solution-phase combinatorial chemistry.

Authors: C M Baldino
Journal: J Comb Chem Date: 2000 Mar-Apr

Review 2. High-speed combinatorial synthesis utilizing microwave irradiation.

Authors: C Oliver Kappe
Journal: Curr Opin Chem Biol Date: 2002-06 Impact factor: 8.822

Review 3. Combinatorial compound libraries for drug discovery: an ongoing challenge.

Authors: H Mario Geysen; Frank Schoenen; David Wagner; Richard Wagner
Journal: Nat Rev Drug Discov Date: 2003-03 Impact factor: 84.694

Review 4. Microwave-assisted polymer-supported combinatorial synthesis.

Authors: K M K Swamy; Wen-Ben Yeh; Mei-Jung Lin; Chung-Ming Sun
Journal: Curr Med Chem Date: 2003-11 Impact factor: 4.530

Review 5. Microwave-accelerated homogeneous catalysis in organic chemistry.

Authors: Mats Larhed; Christina Moberg; Anders Hallberg
Journal: Acc Chem Res Date: 2002-09 Impact factor: 22.384

6. Synthesis of a library of complex macrodiolides employing cyclodimerization of hydroxy esters.

Authors: Aaron B Beeler; Dayle E Acquilano; Qibin Su; Feng Yan; Bryan L Roth; James S Panek; John A Porco
Journal: J Comb Chem Date: 2005 Sep-Oct

Review 7. Fluorous tagging strategy for solution-phase synthesis of small molecules, peptides and oligosaccharides.

Authors: Wei Zhang
Journal: Curr Opin Drug Discov Devel Date: 2004-11

8. Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.

Authors: Craig W Lindsley; Zhijian Zhao; William H Leister; Ronald G Robinson; Stanley F Barnett; Deborah Defeo-Jones; Raymond E Jones; George D Hartman; Joel R Huff; Hans E Huber; Mark E Duggan
Journal: Bioorg Med Chem Lett Date: 2005-02-01 Impact factor: 2.823

9. Fluorous reagents and scavengers versus solid-supported reagents and scavengers, a reaction rate and kinetic comparison.

Authors: Christine Hiu-Tung Chen; Wei Zhang
Journal: Mol Divers Date: 2005 Impact factor: 2.943

10. A new regioselective Heck vinylation with enamides. Synthesis and investigation of fluorous-tagged bidentate ligands for fast separation.

Authors: Karl S A Vallin; Qisheng Zhang; Mats Larhed; Dennis P Curran; Anders Hallberg
Journal: J Org Chem Date: 2003-08-22 Impact factor: 4.354

3 in total