Literature DB >> 12643685

The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography.

Rupert J M Russell1, James B Murray, Georg Lentzen, Jalal Haddad, Shahriar Mobashery.   

Abstract

The ribosome is an important target for aminoglycoside antibiotics; however, the clinical effectiveness of aminoglycosides has diminished due to bacterial resistance mechanisms. Here we report the X-ray structure of a novel synthetic aminoglycoside bound to the A site of the ribosome, its target for manifestation of activity. The structure validates the in silico design paradigms for the antibiotic and reveals the molecular interactions made by this novel antibiotic in prokaryotes.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12643685     DOI： 10.1021/ja029736h

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  14 in total

1.  Three-dimensional motifs from the SCOR, structural classification of RNA database: extruded strands, base triples, tetraloops and U-turns.

Authors:  Peter S Klosterman; Donna K Hendrix; Makio Tamura; Stephen R Holbrook; Steven E Brenner
Journal:  Nucleic Acids Res       Date:  2004-04-30       Impact factor: 16.971

2.  Drug target interaction energies by the kernel energy method in aminoglycoside drugs and ribosomal A site RNA targets.

Authors:  Lulu Huang; Lou Massa; Jerome Karle
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-01       Impact factor: 11.205

Review 3.  Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.

Authors:  Nishad Thamban Chandrika; Sylvie Garneau-Tsodikova
Journal:  Chem Soc Rev       Date:  2018-02-19       Impact factor: 54.564

4.  Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase.

Authors:  Kenward Vong; Karine Auclair
Journal:  Medchemcomm       Date:  2012-04-01       Impact factor: 3.597

5.  Characterization of ribosomal binding and antibacterial activities using two orthogonal high-throughput screens.

Authors:  Ada King; Derrick Watkins; Sunil Kumar; Nihar Ranjan; Changjun Gong; Jarred Whitlock; Dev P Arya
Journal:  Antimicrob Agents Chemother       Date:  2013-07-15       Impact factor: 5.191

6.  Synthesis and antibacterial activity of pyranmycin derivatives with N-1 and O-6 modifications.

Authors:  Jie Li; Fang-I Chiang; Hsiao-Nung Chen; Cheng-Wei Tom Chang
Journal:  Bioorg Med Chem       Date:  2007-09-01       Impact factor: 3.641

7.  Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides.

Authors:  Jun-ichi Wachino; Keigo Shibayama; Hiroshi Kurokawa; Kouji Kimura; Kunikazu Yamane; Satowa Suzuki; Naohiro Shibata; Yasuyoshi Ike; Yoshichika Arakawa
Journal:  Antimicrob Agents Chemother       Date:  2007-09-17       Impact factor: 5.191

8.  Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila.

Authors:  Desiree H Fong; Christopher T Lemke; Jiyoung Hwang; Bing Xiong; Albert M Berghuis
Journal:  J Biol Chem       Date:  2010-01-19       Impact factor: 5.157

9.  Surprising alteration of antibacterial activity of 5"-modified neomycin against resistant bacteria.

Authors:  Jianjun Zhang; Fang-I Chiang; Long Wu; Przemyslaw Greg Czyryca; Ding Li; Cheng-Wei Tom Chang
Journal:  J Med Chem       Date:  2008-12-11       Impact factor: 7.446

10.  Aminoglycosides: molecular insights on the recognition of RNA and aminoglycoside mimics.

Authors:  Maruthi Chittapragada; Sarah Roberts; Young Wan Ham
Journal:  Perspect Medicin Chem       Date:  2009-04-28
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.