| Literature DB >> 12641476 |
Michael W W Adams1, Harry A Dailey, Lawrence J DeLucas, Ming Luo, James H Prestegard, John P Rose, Bi-Cheng Wang.
Abstract
The Southeast Collaboratory for Structural Genomics consists of four working groups. The protein production group supplies/develops high-output production of Pyrococcus furiosus, Caenorhabditis elegans, and selected human proteins. The X-ray crystallography group conducts high-throughput structure production in parallel with production-related research/development in nanocrystallization robotics, capillary crystallization cassette, synchrotron/home X-ray instrumentation, sample mounting robotics, data processing and pipelined structure analysis, combined refinement/validation protocols, and direct use of unlabeled native crystals (Direct Crystallography). The NMR group emphasizes/develops sample screening and backbone structure determination from residual dipolar coupling data. The bioinformatics group implements/develops local database interfaces, pipelined sequence/structure information search/updates, and database/bioinformatics toolkits.Entities:
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Year: 2003 PMID： 12641476 DOI： 10.1021/ar0101382
Source DB: PubMed Journal: Acc Chem Res ISSN： 0001-4842 Impact factor: 22.384