| Literature DB >> 1262467 |
E B Olson, J C Knutson, M H Bhattacharyya, H F DeLuca.
Abstract
The metabolism of [3H]vitamin D3 in hepatectomized vitamin D-deficient rats has been studied. Hepatectomy drastically disrupts vitamin D3 metabolism as revealed by prolonged high levels of [3H] vitamin D3 in the plasma compartment even 12 h after dose in contrast to sham-operated controls. Some conversion of [3H] vitamin D3 to [3H]25-hydroxyvitamin D3 was detected in hepatectomized rats, but the amount was small in spite of the high circulating levels of [3H]vitamin D3. Since the liver initially takes up much of an administered dose in normal animals and the conversion of [3H]vitamin D3 to [3H]25-hydroxyvitamin D3 is small in hepatectomized rats in spite of high circulating [3H]-vitamin D3, it is concluded that the liver plays a major role in the metabolism of vitamin D3 to 25-hydroxy-vitamin D3.Entities:
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Year: 1976 PMID： 1262467 PMCID： PMC436774 DOI： 10.1172/JCI108389
Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808