Literature DB >> 217341

Incorportion of oxygen-18 into the 25-position of cholecalciferol by hepatic cholecalciferol 25-hydroxylase.

T C Madhok, H K Schnoes, H F DeLuca.   

Abstract

The oxygen enzymically inserted as a hydroxy function by rat liver post-mitochondrial fraction into the 25-position of cholecalciferol to giver 25-hydroxycholecaliferol is derived exclusively from molecular O2. Therefore like the other two cholecalciferol hydroxylases, i.e. 25-hydroxycholecalciferol 1alpha-hydroxylase and 25-hydroxycholecalciferol 24-hydroxylase, the cholecalciferol 25-hydroxylase is also a mono-oxygenase ('mixed-function oxidase').

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Year:  1978        PMID： 217341      PMCID： PMC1186094          DOI： 10.1042/bj1750479

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

1.  Mechanism of 25-hydroxyvitamin D3 24-hydroxylation: incorporation of oxygen-18 into the 24 position of 25-hydroxyvitamin D3.

Authors:  T C Madhok; H K Schnoes; H F DeLuca
Journal:  Biochemistry       Date:  1977-05-17       Impact factor: 3.162

2.  A new chromatographic system for vitamin D3 and its metabolites: resoluation of a new vitamin D3 metabolite.

Authors:  M F Holick; H F DeLuca
Journal:  J Lipid Res       Date:  1971-07       Impact factor: 5.922

3.  Subcellular location of rat liver calciferol-25-hydroxylase.

Authors:  M H Bhattacharyya; H F DeLuca
Journal:  Arch Biochem Biophys       Date:  1974-01       Impact factor: 4.013

4.  Vitamin D 3 -25-hydroxylase: tissue occurrence and apparent lack of regulation.

Authors:  G Tucker; R E Gagnon; M R Haussler
Journal:  Arch Biochem Biophys       Date:  1973-03       Impact factor: 4.013

Review 5.  Vitamin D: the vitamin and the hormone.

Authors:  H F DeLuca
Journal:  Fed Proc       Date:  1974-11

6.  The story of vitamin D: from vitamin to hormone.

Authors:  J B Mason; R W Hay; J Leresche; S Peel; S Darley
Journal:  Lancet       Date:  1974-03-02       Impact factor: 79.321

7.  In vitro production of 25-hydroxycholecalciferol.

Authors:  M Horsting; H F DeLuca
Journal:  Biochem Biophys Res Commun       Date:  1969-07-23       Impact factor: 3.575

8.  25-hydroxycholecalciferol. A biologically active metabolite of vitamin D3.

Authors:  J W Blunt; H F DeLuca; H K Schnoes
Journal:  Biochemistry       Date:  1968-10       Impact factor: 3.162

9.  Mitochondrial cytochrome p450. A component of chick kidney 25-hydrocholecalciferol-1alpha-hydroxylase.

Authors:  J G Ghazarian; C R Jefcoate; J C Knutson; W H Orme-Johnson; H F DeLuca
Journal:  J Biol Chem       Date:  1974-05-25       Impact factor: 5.157

10.  25-Hydroxycholecalciferol-1-hydroxylase: a specific requirement for NADPH and a hemoprotein component in chick kidney mitochondria.

Authors:  J G Ghazarian; H F DeLuca
Journal:  Arch Biochem Biophys       Date:  1974-01       Impact factor: 4.013
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  2 in total

1.  Characteristics of the rat liver microsomal enzyme system converting cholecalciferol into 25-hydroxycholecalciferol. Evidence for the participation of cytochrome p-450.

Authors:  T C Madhok; H F DeLuca
Journal:  Biochem J       Date:  1979-12-15       Impact factor: 3.857

2.  Reduction of circulating 25-hydroxyvitamin D by antipyrine.

Authors:  P F Wilmana; M J Brodie; J C Mucklow; H S Fraser; E L Toverud; D S Davies; C T Dollery; C J Hillyard; I Macintyre; B K Park
Journal:  Br J Clin Pharmacol       Date:  1979-12       Impact factor: 4.335
  2 in total

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