Literature DB >> 12618001

Systems biology: integrating technology, biology, and computation.

Leroy Hood1.   

Abstract

The Human Genome Project has changed the worlds of biology and medicine-helping to catalyze two major paradigm changes: systems biology and predictive, preventive and personalized medicine. These two themes will dominate 21st century biology and medicine. I will discuss these changes and indicate how they may interface with with the process of aging.

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Year:  2003        PMID： 12618001     DOI： 10.1016/s0047-6374(02)00164-1

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN： 0047-6374            Impact factor:   5.432


  52 in total

1.  Mathematical algorithm for discovering states of expression from direct genetic comparison by microarrays.

Authors:  Hassan M Fathallah-Shaykh; Bin He; Li-Juan Zhao; Aamir Badruddin
Journal:  Nucleic Acids Res       Date:  2004-07-20       Impact factor: 16.971

2.  Dynamic metabolomic data analysis: a tutorial review.

Authors:  A K Smilde; J A Westerhuis; H C J Hoefsloot; S Bijlsma; C M Rubingh; D J Vis; R H Jellema; H Pijl; F Roelfsema; J van der Greef
Journal:  Metabolomics       Date:  2009-12-04       Impact factor: 4.290

3.  Systematics and the origin of species: an introduction.

Authors:  Jody Hey; Walter M Fitch; Francisco J Ayala
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-25       Impact factor: 11.205

Review 4.  Genomes, phylogeny, and evolutionary systems biology.

Authors:  Mónica Medina
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-25       Impact factor: 11.205

Review 5.  Metabolic engineering in the -omics era: elucidating and modulating regulatory networks.

Authors:  Goutham N Vemuri; Aristos A Aristidou
Journal:  Microbiol Mol Biol Rev       Date:  2005-06       Impact factor: 11.056

6.  Cytomics, the human cytome project and systems biology: top-down resolution of the molecular biocomplexity of organisms by single cell analysis.

Authors:  G Valet
Journal:  Cell Prolif       Date:  2005-08       Impact factor: 6.831

7.  Metabolomics: building on a century of biochemistry to guide human health.

Authors:  J Bruce German; Bruce D Hammock; Steven M Watkins
Journal:  Metabolomics       Date:  2005-03       Impact factor: 4.290

Review 8.  The use of high-dimensional biology (genomics, transcriptomics, proteomics, and metabolomics) to understand the preterm parturition syndrome.

Authors:  R Romero; J Espinoza; F Gotsch; J P Kusanovic; L A Friel; O Erez; S Mazaki-Tovi; N G Than; S Hassan; G Tromp
Journal:  BJOG       Date:  2006-12       Impact factor: 6.531

9.  Global view of bionetwork dynamics: adaptive landscape.

Authors:  Ping Ao
Journal:  J Genet Genomics       Date:  2009-02       Impact factor: 4.275

10.  Exploiting cellular-developmental evolution as the scientific basis for preventive medicine.

Authors:  J S Torday; V K Rehan
Journal:  Med Hypotheses       Date:  2009-01-14       Impact factor: 1.538
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