Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Uptake of 5-hydroxytryptamine by rat blood platelets and its inhibition by adenosine 5'-diphosphate.

Literature DB >> 1260221

Uptake of 5-hydroxytryptamine by rat blood platelets and its inhibition by adenosine 5'-diphosphate.

Abstract

1 The uptake of 5-hydroxytryptamine (5-HT) by rat blood platelets in citrated plasma was linear for at most 10 s and was substantially complete within 3 minutes. 2 Adenosine 5'-diphosphate (ADP) was a potent inhibitor of 5-HT uptake (Ki=0.38 muM) and kinetic analysis revealed that the inhibition was not competitive. 3 Inhibition of 5-HT uptake by ADP was abolished in the presence of prostaglandin E1 and 2-n-amylthio-AMP, which also inhibit the stimulant actions of ADP on blood platelets. 4 It is concluded that ADP could inhibit 5-HT uptake by changing the Na+/K+ distribution across the cell membrane, and the biological significance of this is discussed.

Entities: Chemical Species

Mesh：

Substances：

Year: 1976 PMID： 1260221 PMCID： PMC1666889 DOI： 10.1111/j.1476-5381.1976.tb07452.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

20 in total

1. EFFECT OF IMIPRAMINE AND SOME ANALOGUES ON THE UPTAKE OF 5-HYDROXYTRYPTAMINE BY HUMAN BLOOD PLATELETS IN VITRO.

Authors: C M YATES; A TODRICK; A C TAIT
Journal: J Pharm Pharmacol Date: 1964-07 Impact factor: 3.765

2. Adenosine diphosphate in red cells as a factor in the adhesiveness of human blood platelets.

Authors: A GAARDER; J JONSEN; S LALAND; A HELLEM; P A OWREN
Journal: Nature Date: 1961-11-11 Impact factor: 49.962

3. Effect of fenfluramine on 5-hydroxytryptamine uptake and release by rat blood platelets.

Authors: W Buczko; G De Gaetano; S Garattini
Journal: Br J Pharmacol Date: 1975-04 Impact factor: 8.739

4. Binding of adenosine diphosphate by isolated membranes from human platelets.

Authors: R L Nachman; B Ferris
Journal: J Biol Chem Date: 1974-02-10 Impact factor: 5.157

5. Mechanism of biogenic amine transport. II. Relationship between sodium and the mechanism of ouabain blockade of the accumulation of serotonin and norepinephrine by synaptosomes.

Authors: A H Tissari; P S Schönhöfer; D F Bogdanski; B B Brodie
Journal: Mol Pharmacol Date: 1969-11 Impact factor: 4.436

6. Letter: Rapid, sensitive microassay for platelet 5HT.

Authors: A H Drummond; J L Gordon
Journal: Thromb Diath Haemorrh Date: 1974-05-15

7. Effects of 5-hydroxytryptamine on platelet aggregation.

Authors: H R Baumgartner; G V Born
Journal: Nature Date: 1968-04-13 Impact factor: 49.962

8. A new modification for studying 5-HT uptake by blood platelets: a re-evaluation of tricyclic antidepressants as uptake inhibitors.

Authors: J Tuomisto
Journal: J Pharm Pharmacol Date: 1974-02 Impact factor: 3.765

9. Uptake of adenosine and of adenosine diphosphate by human blood platelets.

Authors: G V Born
Journal: Nature Date: 1965-06-12 Impact factor: 49.962

10. Specific binding sites for 5-hydroxytryptamine on rat blood platelets.

Authors: A H Drummond; J L Gordon
Journal: Biochem J Date: 1975-07 Impact factor: 3.857

7 in total

1. Transport of 5-hydroxytryptamine by rat and human platelets [proceedings].

Authors: J L Gordon; H J Overman
Journal: Br J Pharmacol Date: 1976-10 Impact factor: 8.739

2. Transport of dopamine by rat blood platelets [proceedings].

Authors: J L Gordon; H J Olverman
Journal: Br J Pharmacol Date: 1977-09 Impact factor: 8.739

3. Uptake of 14C-5-hydroxytryptamine by human and rat platelets and its pharmacological inhibition. A comparative kinetic analysis.

Authors: M Wielosz; M Salmona; G de Gaetano; S Garattini
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1976-12 Impact factor: 3.000