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Literature DB >> 1201004

Specific binding sites for 5-hydroxytryptamine on rat blood platelets.

Abstract

5-Hydroxytryptamine changes the shape of rat blood platelets by combination with a cinanserin-sensitive receptor which is not associated with the active uptake of 5-hydroxytryptamine. Binding of 5-hydroxy[3H]tryptamine to platelets at 4 degrees C demonstrates the presence of three saturable sites, and the highest-affinity site is apparently this 5-hydroxytryptamine receptor.

Entities: Chemical Species

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Year: 1975 PMID： 1201004 PMCID： PMC1165712 DOI： 10.1042/bj1500129

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

12 in total

1. A NEW, POTENT AND SPECIFIC SEROTONIN INHIBITOR, (SQ 10,643) 2'-(3-DIMETHYLAMINOPROPYLTHIO) CINNAMANILIDE HYDROCHLORIDE: ANTISEROTONIN ACTIVITY ON UTERUS AND ON GASTROINTESTINAL, VASCULAR, AND RESPIRATORY SYSTEMS OF ANIMALS.

Authors: B RUBIN; J J PIALA; J C BURKE; B N CRAVER
Journal: Arch Int Pharmacodyn Ther Date: 1964-11-01

2. PLATELET CLUMPING IN VITRO.

Authors: J R MITCHELL; A A SHARP
Journal: Br J Haematol Date: 1964-01 Impact factor: 6.998

3. A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine.

Authors: D T Wong; J S Horng; F P Bymaster; K L Hauser; B B Molloy
Journal: Life Sci Date: 1974-08-01 Impact factor: 5.037

4. Letter: Rapid, sensitive microassay for platelet 5HT.

Authors: A H Drummond; J L Gordon
Journal: Thromb Diath Haemorrh Date: 1974-05-15

5. Effects of 5-hydroxytryptamine on platelet aggregation.

Authors: H R Baumgartner; G V Born
Journal: Nature Date: 1968-04-13 Impact factor: 49.962

6. 5-Hydroxytryptamine uptake and release in relation to aggregation of rabbit platelets.

Authors: H R Baumgartner
Journal: J Physiol Date: 1969-04 Impact factor: 5.182

7. The relation between the 5-hydroxytryptamine content and aggregation of rabbit platelets.

Authors: H R Baumgartner; G V Born
Journal: J Physiol Date: 1969-04 Impact factor: 5.182

8. Relative activities on and uptake by human blood platelets of 5-hydroxytryptamine and several analogues.

Authors: G V Born; K Juengjaroen; F Michal
Journal: Br J Pharmacol Date: 1972-01 Impact factor: 8.739

9. A simple fluorimetric microassay for adenine compounds in platelets and plasma and its application to studies on the platelet release reaction.

Authors: J L Gordon; A H Drummond
Journal: Biochem J Date: 1974-02 Impact factor: 3.857

10. [On the pharmacology of tofranil (N-(3-dimethylaminopropyl)-iminodibenzyl hydrochloride].

Authors: R DOMENJOZ; W THEOBALD
Journal: Arch Int Pharmacodyn Ther Date: 1959-07-01

8 in total

1. Proceedings: Inhibition of 5-hydroxy-(3H)-tryptamine binding to rat blood platelets by 5-HT antagonists and uptake inhibitors.

Authors: A H Drummond; J L Gordon
Journal: Br J Pharmacol Date: 1975-10 Impact factor: 8.739

2. Binding of 5-hydroxytryptamine to human blood platelets [proceedings].

Authors: D J Boullin; P A Glenton; D Molyneux; J R Peters; B Roach
Journal: Br J Pharmacol Date: 1977-11 Impact factor: 8.739

3. Uptake of 14C-5-hydroxytryptamine by human and rat platelets and its pharmacological inhibition. A comparative kinetic analysis.

Authors: M Wielosz; M Salmona; G de Gaetano; S Garattini
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1976-12 Impact factor: 3.000

Review 8. Platelets as a model for neurones?

Authors: M Da Prada; A M Cesura; J M Launay; J G Richards
Journal: Experientia Date: 1988-02-15