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Literature DB >> 12567284

Potential antitumor promoting diterpenoids from the stem bark of Thuja standishii.

Manabu Iwamoto, Toshifumi Minami, Harukuni Tokuda, Hironori Ohtsu, Reiko Tanaka.

Abstract

Six diterpenes, including one new natural product, were isolated from a CHCl 3 extract of the stem bark of Thuja standishii. The new compound has been characterized as 15-oxolabda-8(17),13 Z-dien-19-oic acid. The known compounds were identified as ferruginol (2), sugiol (3), isocupressic acid (4), sandaracopimaric acid (5) and 15-oxolabda-8(17),13 E-dien-19-oic acid (6). Compounds 2-5 and the derivatives 4a and 4b were tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA). Compounds 2, 3, 4 and 5 showed strong inhibitory effect on EBV-EA induction (100 % inhibition at 1000 mol ratio/TPA).

Entities: Chemical Species

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Year: 2003 PMID： 12567284 DOI： 10.1055/s-2003-37037

Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352

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Cited

7 in total

1. Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells.

Authors: M R Loizzo; R Tundis; F Menichini; A M Saab; G A Statti; F Menichini
Journal: Cell Prolif Date: 2008-12 Impact factor: 6.831

2. 6-Hydr-oxy-7-isopropyl-1,1,4a-trimethyl-2,3,4,4a,10,10a-hexa-hydro-phenanthren-9(1H)-one.

Authors: Nezha Rajouani; My Youssef Ait Itto; Ahmed Benharref; Aziz Auhmani; Jean-Claude Daran
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2008-03-29

3. Towards Elucidating Carnosic Acid Biosynthesis in Lamiaceae: Functional Characterization of the Three First Steps of the Pathway in Salvia fruticosa and Rosmarinus officinalis.

Authors: Dragana Božić; Dimitra Papaefthimiou; Kathleen Brückner; Ric C H de Vos; Constantinos A Tsoleridis; Dimitra Katsarou; Antigoni Papanikolaou; Irini Pateraki; Fani M Chatzopoulou; Eleni Dimitriadou; Stefanos Kostas; David Manzano; Ulschan Scheler; Albert Ferrer; Alain Tissier; Antonios M Makris; Sotirios C Kampranis; Angelos K Kanellis
Journal: PLoS One Date: 2015-05-28 Impact factor: 3.240

Potential antitumor promoting diterpenoids from the stem bark of Thuja standishii.

1. Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells.

2. 6-Hydr-oxy-7-isopropyl-1,1,4a-trimethyl-2,3,4,4a,10,10a-hexa-hydro-phenanthren-9(1H)-one.

3. Towards Elucidating Carnosic Acid Biosynthesis in Lamiaceae: Functional Characterization of the Three First Steps of the Pathway in Salvia fruticosa and Rosmarinus officinalis.

4. Crystal structure of (4bS,8aR)-1-isopropyl-4b,8,8-trimethyl-7-oxo-4b,7,8,8a,9,10-hexa-hydro-phenanthren-2-yl acetate.

5. Resin diterpenes from Austrocedrus chilensis.

Review 6. Thuja occidentalis L. (Cupressaceae): Ethnobotany, Phytochemistry and Biological Activity.

7. Successful Treatment of Chronic Viral Hepatitis With High-dilution Medicine.