Literature DB >> 12563306

Modern biomedical research: an internally self-consistent universe with little contact with medical reality?

David F Horrobin1.   

Abstract

Mesh:

Year:  2003        PMID: 12563306     DOI: 10.1038/nrd1012

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN: 1474-1776            Impact factor:   84.694


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  49 in total

Review 1.  From basic to clinical neuropharmacology: targetophilia or pharmacodynamics?

Authors:  A Richard Green; Jeffrey K Aronson
Journal:  Br J Clin Pharmacol       Date:  2012-06       Impact factor: 4.335

Review 2.  Diagnosing the decline in pharmaceutical R&D efficiency.

Authors:  Jack W Scannell; Alex Blanckley; Helen Boldon; Brian Warrington
Journal:  Nat Rev Drug Discov       Date:  2012-03-01       Impact factor: 84.694

3.  Reductionism and complexity in molecular biology. Scientists now have the tools to unravel biological and overcome the limitations of reductionism.

Authors:  Marc H V Van Regenmortel
Journal:  EMBO Rep       Date:  2004-11       Impact factor: 8.807

Review 4.  Strategic challenges in neurotherapeutic pharmaceutical development.

Authors:  Christopher C Gallen
Journal:  NeuroRx       Date:  2004-01

5.  VeloceGenomics: an accelerated in vivo drug discovery approach to rapidly predict the biologic, drug-like activity of compounds, proteins, or genes.

Authors:  Ruben Papoian; Andreas Scherer; Muriel Saulnier; Frank Staedtler; André Cordier; Francois Legay; Gerard Maurer; Joerg Staeheli; Jacky Vonderscher; Salah-Dine Chibout
Journal:  Pharm Res       Date:  2005-09-22       Impact factor: 4.200

6.  The phase 0 microdosing concept.

Authors:  R Colin Garner; Graham Lappin
Journal:  Br J Clin Pharmacol       Date:  2006-04       Impact factor: 4.335

7.  Complexity in biology. Exceeding the limits of reductionism and determinism using complexity theory.

Authors:  Fulvio Mazzocchi
Journal:  EMBO Rep       Date:  2008-01       Impact factor: 8.807

8.  The need for transparency and good practices in the qPCR literature.

Authors:  Stephen A Bustin; Vladimir Benes; Jeremy Garson; Jan Hellemans; Jim Huggett; Mikael Kubista; Reinhold Mueller; Tania Nolan; Michael W Pfaffl; Gregory Shipley; Carl T Wittwer; Peter Schjerling; Philip J Day; Mónica Abreu; Begoña Aguado; Jean-François Beaulieu; Anneleen Beckers; Sara Bogaert; John A Browne; Fernando Carrasco-Ramiro; Liesbeth Ceelen; Kate Ciborowski; Pieter Cornillie; Stephanie Coulon; Ann Cuypers; Sara De Brouwer; Leentje De Ceuninck; Jurgen De Craene; Hélène De Naeyer; Ward De Spiegelaere; Kato Deckers; Annelies Dheedene; Kaat Durinck; Margarida Ferreira-Teixeira; Annelies Fieuw; Jack M Gallup; Sandra Gonzalo-Flores; Karen Goossens; Femke Heindryckx; Elizabeth Herring; Hans Hoenicka; Laura Icardi; Rolf Jaggi; Farzad Javad; Michael Karampelias; Frederick Kibenge; Molly Kibenge; Candy Kumps; Irina Lambertz; Tim Lammens; Amelia Markey; Peter Messiaen; Evelien Mets; Sofia Morais; Alberto Mudarra-Rubio; Justine Nakiwala; Hilde Nelis; Pal A Olsvik; Claudina Pérez-Novo; Michelle Plusquin; Tony Remans; Ali Rihani; Paulo Rodrigues-Santos; Pieter Rondou; Rebecca Sanders; Katharina Schmidt-Bleek; Kerstin Skovgaard; Karen Smeets; Laura Tabera; Stefan Toegel; Tim Van Acker; Wim Van den Broeck; Joni Van der Meulen; Mireille Van Gele; Gert Van Peer; Mario Van Poucke; Nadine Van Roy; Sarah Vergult; Joris Wauman; Marina Tshuikina-Wiklander; Erik Willems; Sara Zaccara; Fjoralba Zeka; Jo Vandesompele
Journal:  Nat Methods       Date:  2013-11       Impact factor: 28.547

9.  Development of a metastatic murine colon cancer model.

Authors:  Krista P Terracina; Tomoyoshi Aoyagi; Wei-Ching Huang; Masayuki Nagahashi; Akimitsu Yamada; Kazunori Aoki; Kazuaki Takabe
Journal:  J Surg Res       Date:  2015-04-15       Impact factor: 2.192

10.  Binding of NIR-conPK and NIR-6T to astrocytomas and microglial cells: evidence for a protein related to TSPO.

Authors:  Michelle Sexton; Grace Woodruff; Eiron Cudaback; Faith R Kreitzer; Cong Xu; Yi Hsing Lin; Thomas Möller; Mingfeng Bai; H Charles Manning; Darryl Bornhop; Nephi Stella
Journal:  PLoS One       Date:  2009-12-18       Impact factor: 3.240

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