Literature DB >> 12543654

Activity of tigecycline (GAR-936), a novel glycylcycline, against Enterococci in the mouse peritonitis model.

Esteban C Nannini1, Suresh R Pai, Kavindra V Singh, Barbara E Murray.   

Abstract

A novel glycylcycline agent, tigecycline (GAR-936), was evaluated in vivo in the mouse model of peritonitis against three Enterococcus faecalis and four Enterococcus faecium isolates with different susceptibilities to vancomycin and tetracyclines, all of which were inhibited by </=0.125 micro g of tigecycline/ml. Using a single subcutaneous dose, tigecycline displayed a protective effect (50% protective dose, </=5.7 mg/kg of body weight) against all strains tested, including two with Tn925 (from the Tn916 family), which contains the Tet(M) tetracycline resistance determinant, as well as VanA and VanB strains. As expected, tetracycline and minocycline were ineffective against the isolates carrying Tn925.

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Year:  2003        PMID： 12543654      PMCID： PMC151755          DOI： 10.1128/AAC.47.2.529-532.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Antimicrobial activity and spectrum of the new glycylcycline, GAR-936 tested against 1,203 recent clinical bacterial isolates.

Authors:  A C Gales; R N Jones
Journal:  Diagn Microbiol Infect Dis       Date:  2000-01       Impact factor: 2.803

2.  National Nosocomial Infections Surveillance (NNIS) System Report, Data Summary from January 1992-June 2001, issued August 2001.

Authors: 
Journal:  Am J Infect Control       Date:  2001-12       Impact factor: 2.918

Review 3.  The life and times of the Enterococcus.

Authors:  B E Murray
Journal:  Clin Microbiol Rev       Date:  1990-01       Impact factor: 26.132

4.  Generation of restriction map of Enterococcus faecalis OG1 and investigation of growth requirements and regions encoding biosynthetic function.

Authors:  B E Murray; K V Singh; R P Ross; J D Heath; G M Dunny; G M Weinstock
Journal:  J Bacteriol       Date:  1993-08       Impact factor: 3.490

5.  Nosocomial bloodstream infections in United States hospitals: a three-year analysis.

Authors:  M B Edmond; S E Wallace; D K McClish; M A Pfaller; R N Jones; R P Wenzel
Journal:  Clin Infect Dis       Date:  1999-08       Impact factor: 9.079

6.  Efficacy of telithromycin (HMR 3647) against enterococci in a mouse peritonitis model.

Authors:  K V Singh; K K Zscheck; B E Murray
Journal:  Antimicrob Agents Chemother       Date:  2000-12       Impact factor: 5.191

7.  Therapeutic efficacy of GAR-936, a novel glycylcycline, in a rat model of experimental endocarditis.

Authors:  T M Murphy; J M Deitz; P J Petersen; S M Mikels; W J Weiss
Journal:  Antimicrob Agents Chemother       Date:  2000-11       Impact factor: 5.191

8.  In vitro susceptibility studies of vancomycin-resistant Enterococcus faecalis.

Authors:  D F Sahm; J Kissinger; M S Gilmore; P R Murray; R Mulder; J Solliday; B Clarke
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

9.  Resistance of Enterococcus faecium to neutrophil-mediated phagocytosis.

Authors:  R C Arduino; K Jacques-Palaz; B E Murray; R M Rakita
Journal:  Infect Immun       Date:  1994-12       Impact factor: 3.441

10.  The conjugative transposon Tn925: enhancement of conjugal transfer by tetracycline in Enterococcus faecalis and mobilization of chromosomal genes in Bacillus subtilis and E. faecalis.

Authors:  O R Torres; R Z Korman; S A Zahler; G M Dunny
Journal:  Mol Gen Genet       Date:  1991-03
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  9 in total

1.  Efficacy of Tedizolid against Enterococci and Staphylococci, Including cfr + Strains, in a Mouse Peritonitis Model.

Authors:  Kavindra V Singh; Cesar A Arias; Barbara E Murray
Journal:  Antimicrob Agents Chemother       Date:  2019-03-27       Impact factor: 5.191

2.  Effects of age and sex on single-dose pharmacokinetics of tigecycline in healthy subjects.

Authors:  Gopal Muralidharan; Richard J Fruncillo; Marlynne Micalizzi; Donald G Raible; Steven M Troy
Journal:  Antimicrob Agents Chemother       Date:  2005-04       Impact factor: 5.191

3.  Activity of antimicrobial combinations against KPC-2-producing Klebsiella pneumoniae in a rat model and time-kill assay.

Authors:  Paula Virginia Michelon Toledo; Ayrton Alves Aranha Junior; Lavinia Nery Arend; Vanessa Ribeiro; Alexandre Prehn Zavascki; Felipe Francisco Tuon
Journal:  Antimicrob Agents Chemother       Date:  2015-04-20       Impact factor: 5.191

4.  Synthesis and evaluation of 1,2,4-triazolo[1,5-a]pyrimidines as antibacterial agents against Enterococcus faecium.

Authors:  Huan Wang; Mijoon Lee; Zhihong Peng; Blas Blázquez; Elena Lastochkin; Malika Kumarasiri; Renee Bouley; Mayland Chang; Shahriar Mobashery
Journal:  J Med Chem       Date:  2015-05-12       Impact factor: 7.446

Review 5.  Tigecycline: a novel glycylcycline.

Authors:  Ethan Rubinstein; David Vaughan
Journal:  Drugs       Date:  2005       Impact factor: 9.546

Review 6.  Clinical pharmacokinetics and pharmacodynamics of tigecycline.

Authors:  April Barbour; Stephan Schmidt; Benjamin Ma; Lars Schiefelbein; Kenneth H Rand; Olaf Burkhardt; Hartmut Derendorf
Journal:  Clin Pharmacokinet       Date:  2009       Impact factor: 6.447

7.  Dogs leaving the ICU carry a very large multi-drug resistant enterococcal population with capacity for biofilm formation and horizontal gene transfer.

Authors:  Anuradha Ghosh; Scot E Dowd; Ludek Zurek
Journal:  PLoS One       Date:  2011-07-19       Impact factor: 3.240

8.  Tigecycline: an evidence-based review of its antibacterial activity and effectiveness in complicated skin and soft tissue and intraabdominal infections.

Authors:  Christopher J Dunn
Journal:  Core Evid       Date:  2006-03-31

9.  Efficacy of Omadacycline against Multidrug-Resistant Enterococcus faecium Strains in a Mouse Peritonitis Model.

Authors:  Kavindra V Singh; Cesar A Arias; Barbara E Murray
Journal:  Antimicrob Agents Chemother       Date:  2021-08-17       Impact factor: 5.191
  9 in total

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