Literature DB >> 34125596

Efficacy of Omadacycline against Multidrug-Resistant Enterococcus faecium Strains in a Mouse Peritonitis Model.

Kavindra V Singh1,2, Cesar A Arias1,3,4,2,5, Barbara E Murray1,3,2.   

Abstract

Omadacycline (OMC) showed better in vitro potency than daptomycin (DAP) or vancomycin (VAN) against Vanr, Ampr, DAP-nonsusceptible, linezolid-resistant, cfr(B)+ Enterococcus faecium strains. In a mouse peritonitis model, OMC also showed significantly better animal survival during the study and at its end than DAP or VAN with these E. faecium strains. However, OMC, DAP, and VAN showed comparable in vitro and in vivo efficacies against a non-vancomycin-resistant, tetracycline-resistant, DAP-susceptible E. faecium strain.

Entities:  

Keywords:  E. faecium; mouse peritonitis; omadacycline

Mesh：

Substances：

Year:  2021        PMID： 34125596      PMCID： PMC8370196          DOI： 10.1128/AAC.00709-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

Review 1.  Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines.

Authors:  Kenneth N Agwuh; Alasdair MacGowan
Journal:  J Antimicrob Chemother       Date:  2006-07-01       Impact factor: 5.790

2.  Disrupting Membrane Adaptation Restores In Vivo Efficacy of Antibiotics Against Multidrug-Resistant Enterococci and Potentiates Killing by Human Neutrophils.

Authors:  Sandra Rincon; Diana Panesso; William R Miller; Kavindra V Singh; Melissa R Cruz; Ayesha Khan; An Q Dinh; Lorena Diaz; Rafael Rios; Yousif Shamoo; Jinnethe Reyes; Truc T Tran; Danielle A Garsin; Cesar A Arias
Journal:  J Infect Dis       Date:  2019-07-02       Impact factor: 5.226

3.  Efficacy of telavancin (TD-6424), a rapidly bactericidal lipoglycopeptide with multiple mechanisms of action, in a murine model of pneumonia induced by methicillin-resistant Staphylococcus aureus.

Authors:  Noe Reyes; Robert Skinner; Koné Kaniga; Kevin M Krause; Josephine Shelton; Glenmar P Obedencio; Alexander Gough; Michael Conner; Sharath S Hegde
Journal:  Antimicrob Agents Chemother       Date:  2005-10       Impact factor: 5.191

4.  In Vivo Pharmacodynamics of Omadacycline against Staphylococcus aureus in the Neutropenic Murine Thigh Infection Model.

Authors:  Alexander J Lepak; Miao Zhao; Karen Marchillo; Jamie VanHecker; David R Andes
Journal:  Antimicrob Agents Chemother       Date:  2019-06-24       Impact factor: 5.191

5.  Dissecting the mechanisms of linezolid resistance in a Drosophila melanogaster infection model of Staphylococcus aureus.

Authors:  Lorena Diaz; Dimitrios P Kontoyiannis; Diana Panesso; Nathaniel D Albert; Kavindra V Singh; Truc T Tran; Jose M Munita; Barbara E Murray; Cesar A Arias
Journal:  J Infect Dis       Date:  2013-04-01       Impact factor: 5.226

Review 6.  Omadacycline: development of a novel aminomethylcycline antibiotic for treating drug-resistant bacterial infections.

Authors:  Stephen Villano; Judith Steenbergen; Evan Loh
Journal:  Future Microbiol       Date:  2016-08-19       Impact factor: 3.165

7.  Surveillance of omadacycline activity tested against clinical isolates from the United States and Europe: Results from the SENTRY Antimicrobial Surveillance Programme, 2017.

Authors:  Michael D Huband; Michael A Pfaller; Dee Shortridge; Robert K Flamm
Journal:  J Glob Antimicrob Resist       Date:  2019-02-27       Impact factor: 4.035

8.  Contribution of the collagen adhesin Acm to pathogenesis of Enterococcus faecium in experimental endocarditis.

Authors:  Sreedhar R Nallapareddy; Kavindra V Singh; Barbara E Murray
Journal:  Infect Immun       Date:  2008-06-30       Impact factor: 3.441

9.  Complete genome sequence of Enterococcus faecium strain TX16 and comparative genomic analysis of Enterococcus faecium genomes.

Authors:  Xiang Qin; Jessica R Galloway-Peña; Jouko Sillanpaa; Jung Hyeob Roh; Sreedhar R Nallapareddy; Shahreen Chowdhury; Agathe Bourgogne; Tina Choudhury; Donna M Muzny; Christian J Buhay; Yan Ding; Shannon Dugan-Rocha; Wen Liu; Christie Kovar; Erica Sodergren; Sarah Highlander; Joseph F Petrosino; Kim C Worley; Richard A Gibbs; George M Weinstock; Barbara E Murray
Journal:  BMC Microbiol       Date:  2012-07-07       Impact factor: 3.605

10.  Microbiology and Preclinical Review of Omadacycline.

Authors:  James A Karlowsky; Judith Steenbergen; George G Zhanel
Journal:  Clin Infect Dis       Date:  2019-08-01       Impact factor: 9.079
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.