A Lassnigg1, A Punz, R Barker, P Keznickl, N Manhart, E Roth, M Hiesmayr. 1. Department of Cardiothoracic Anaesthesia and Intensive Care Medicine, University Hospital of Vienna, Waehringer Guertel 18-20, A-1090 Wien, Austria. andrea.lassnigg@univie.ac.at
Abstract
BACKGROUND: I.V. infusions of vitamin E emulsion (all-rac-alpha-tocopherol) may reduce ischaemia-reperfusion injuryafter elective cardiac surgery. METHODS:Forty patients participated in a prospective, double-blind, placebo-controlled, randomized trial, receiving either placebo or four doses (270 mg each) of all-rac-alpha-tocopherol between 16 h before and 48 h after surgery. We determined plasma concentrations of vitamin E, vitamin C, malondialdehyde, creatine kinase, troponin I and interleukin 6 and other measures of clinical outcome. RESULTS: Infusion of vitamin E caused normalization of vitamin E plasma concentrations during and after surgery, but had no effect on the early increase in malondialdehyde concentration or the decreases in antioxidative capacity and the water-soluble antioxidant vitamin C. CONCLUSIONS: Normalization of plasma vitamin E concentrations with parenteral vitamin E emulsion does not affect biochemical markers of myocardial injury and does not affect clinical outcome after cardiac surgery.
RCT Entities:
BACKGROUND: I.V. infusions of vitamin E emulsion (all-rac-alpha-tocopherol) may reduce ischaemia-reperfusion injury after elective cardiac surgery. METHODS: Forty patients participated in a prospective, double-blind, placebo-controlled, randomized trial, receiving either placebo or four doses (270 mg each) of all-rac-alpha-tocopherol between 16 h before and 48 h after surgery. We determined plasma concentrations of vitamin E, vitamin C, malondialdehyde, creatine kinase, troponin I and interleukin 6 and other measures of clinical outcome. RESULTS: Infusion of vitamin E caused normalization of vitamin E plasma concentrations during and after surgery, but had no effect on the early increase in malondialdehyde concentration or the decreases in antioxidative capacity and the water-soluble antioxidant vitamin C. CONCLUSIONS: Normalization of plasma vitamin E concentrations with parenteral vitamin E emulsion does not affect biochemical markers of myocardial injury and does not affect clinical outcome after cardiac surgery.
Authors: Pierre-Christian Violet; Ifechukwude C Ebenuwa; Yu Wang; Mahtab Niyyati; Sebastian J Padayatty; Brian Head; Kenneth Wilkins; Stacey Chung; Varsha Thakur; Lynn Ulatowski; Jeffrey Atkinson; Mikel Ghelfi; Sheila Smith; Hongbin Tu; Gerd Bobe; Chia-Ying Liu; David W Herion; Robert D Shamburek; Danny Manor; Maret G Traber; Mark Levine Journal: JCI Insight Date: 2020-01-16
Authors: Martin J Duffy; Cecilia M O'Kane; Michael Stevenson; Ian S Young; Denis W Harkin; Brian A Mullan; Daniel F McAuley Journal: Intensive Care Med Exp Date: 2015-07-01
Authors: Ramón Rodrigo; Daniel Hasson; Juan C Prieto; Gastón Dussaillant; Cristóbal Ramos; Lucio León; Javier Gárate; Nicolás Valls; Juan G Gormaz Journal: Trials Date: 2014-05-29 Impact factor: 2.279