| Literature DB >> 12531877 |
Jacqueline D Trudeau1, Carolyn Kelly-Smith, C Bruce Verchere, John F Elliott, Jan P Dutz, Diane T Finegood, Pere Santamaria, Rusung Tan.
Abstract
Autoimmune (type 1) diabetes mellitus results from the destruction of insulin-producing pancreatic beta cells by T lymphocytes. Prediction of cell-mediated autoimmune diseases by direct detection of autoreactive T cells in peripheral blood has proved elusive, in part because of their low frequency and reduced avidity for peptide MHC ligands. This article was published online in advance of the print edition. The date of publication is available from the JCI website, http://www.jci.org.Entities:
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Year: 2003 PMID: 12531877 PMCID: PMC151866 DOI: 10.1172/JCI16409
Source DB: PubMed Journal: J Clin Invest ISSN: 0021-9738 Impact factor: 14.808