Literature DB >> 12150886

Autoreactive CD8 T cells in organ-specific autoimmunity: emerging targets for therapeutic intervention.

Roland S Liblau1, F Susan Wong, Lennart T Mars, Pere Santamaria.   

Abstract

The importance of CD8 T cells in the pathogenesis of organ-specific autoimmune diseases has not previously been well recognized. Recent evidence, however, indicates that autoreactive CD8 T cells can contribute substantially to tissue damage in both murine and human autoimmune disorders. As such, these T cells now become an attractive target for therapeutic intervention.

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Year:  2002        PMID： 12150886     DOI： 10.1016/s1074-7613(02)00338-2

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  61 in total

Review 1.  Tolerance and autoimmunity in the eye: a role for CD8 T cells in organ-specific autoimmunity in the retina.

Authors:  John V Forrester; Richard J Cornall
Journal:  Immunology       Date:  2003-11       Impact factor: 7.397

2.  Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood.

Authors:  Jacqueline D Trudeau; Carolyn Kelly-Smith; C Bruce Verchere; John F Elliott; Jan P Dutz; Diane T Finegood; Pere Santamaria; Rusung Tan
Journal:  J Clin Invest       Date:  2003-01       Impact factor: 14.808

3.  Enumerating autoreactive T cells in peripheral blood: a big step in diabetes prediction.

Authors:  George S Eisenbarth; Brian L Kotzin
Journal:  J Clin Invest       Date:  2003-01       Impact factor: 14.808

Review 4.  Effector lymphocytes in islet cell autoimmunity.

Authors:  Pere Santamaria
Journal:  Rev Endocr Metab Disord       Date:  2003-09       Impact factor: 6.514

5.  The pathogenicity of self-antigen decreases at high levels of autoantigenicity: a computational approach.

Authors:  Anmar Khadra; Pere Santamaria; Leah Edelstein-Keshet
Journal:  Int Immunol       Date:  2010-05-24       Impact factor: 4.823

Review 6.  The role of lymphocytes in the development and treatment of alopecia areata.

Authors:  Hongwei Guo; Yabin Cheng; Jerry Shapiro; Kevin McElwee
Journal:  Expert Rev Clin Immunol       Date:  2015-09-07       Impact factor: 4.473

7.  Modulation of PD-L1 and CD8 Activity in Idiopathic and Infectious Chronic Inflammatory Conditions.

Authors:  Louisa Mezache; Cynthia Magro; Craig Hofmeister; Flavia Pichiorri; Douglas Sborov; Gerard J Nuovo
Journal:  Appl Immunohistochem Mol Morphol       Date:  2017-02

8.  Continuum model of T-cell avidity: Understanding autoreactive and regulatory T-cell responses in type 1 diabetes.

Authors:  Majid Jaberi-Douraki; Massimo Pietropaolo; Anmar Khadra
Journal:  J Theor Biol       Date:  2015-08-10       Impact factor: 2.691

9.  CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.

Authors:  Ania Skowera; Richard J Ellis; Ruben Varela-Calviño; Sefina Arif; Guo Cai Huang; Cassie Van-Krinks; Anna Zaremba; Chloe Rackham; Jennifer S Allen; Timothy I M Tree; Min Zhao; Colin M Dayan; Andrew K Sewell; Wendy W Unger; Wendy Unger; Jan W Drijfhout; Ferry Ossendorp; Bart O Roep; Mark Peakman
Journal:  J Clin Invest       Date:  2008-10       Impact factor: 14.808

10.  Impaired CD4 and CD8 T cell phenotype and reduced chemokine secretion in recent-onset type 1 diabetic children.

Authors:  M Hedman; M Faresjö; S Axelsson; J Ludvigsson; R Casas
Journal:  Clin Exp Immunol       Date:  2008-09       Impact factor: 4.330
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