Literature DB >> 12522258

ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation.

Daniel Zilberman1, Xiaofeng Cao, Steven E Jacobsen.   

Abstract

Proteins of the ARGONAUTE family are important in diverse posttranscriptional RNA-mediated gene-silencing systems as well as in transcriptional gene silencing in Drosophila and fission yeast and in programmed DNA elimination in Tetrahymena. We cloned ARGONAUTE4 (AGO4) from a screen for mutants that suppress silencing of the Arabidopsis SUPERMAN (SUP) gene. The ago4-1 mutant reactivated silent SUP alleles and decreased CpNpG and asymmetric DNA methylation as well as histone H3 lysine-9 methylation. In addition, ago4-1 blocked histone and DNA methylation and the accumulation of 25-nucleotide small interfering RNAs (siRNAs) that correspond to the retroelement AtSN1. These results suggest that AGO4 and long siRNAs direct chromatin modifications, including histone methylation and non-CpG DNA methylation.

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Year:  2003        PMID： 12522258     DOI： 10.1126/science.1079695

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  411 in total

1.  The microRNAs of Caenorhabditis elegans.

Authors:  Lee P Lim; Nelson C Lau; Earl G Weinstein; Aliaa Abdelhakim; Soraya Yekta; Matthew W Rhoades; Christopher B Burge; David P Bartel
Journal:  Genes Dev       Date:  2003-04-02       Impact factor: 11.361

2.  Virus-induced gene silencing of argonaute genes in Nicotiana benthamiana demonstrates that extensive systemic silencing requires Argonaute1-like and Argonaute4-like genes.

Authors:  Louise Jones; Teresa Keining; Andrew Eamens; Fabián E Vaistij
Journal:  Plant Physiol       Date:  2006-04-21       Impact factor: 8.340

Review 3.  RNA interference: biology, mechanism, and applications.

Authors:  Neema Agrawal; P V N Dasaradhi; Asif Mohmmed; Pawan Malhotra; Raj K Bhatnagar; Sunil K Mukherjee
Journal:  Microbiol Mol Biol Rev       Date:  2003-12       Impact factor: 11.056

4.  Genes and transposons are differentially methylated in plants, but not in mammals.

Authors:  Pablo D Rabinowicz; Lance E Palmer; Bruce P May; Michael T Hemann; Scott W Lowe; W Richard McCombie; Robert A Martienssen
Journal:  Genome Res       Date:  2003-12       Impact factor: 9.043

5.  Argonaute protein in the early divergent eukaryote Trypanosoma brucei: control of small interfering RNA accumulation and retroposon transcript abundance.

Authors:  Huafang Shi; Appolinaire Djikeng; Christian Tschudi; Elisabetta Ullu
Journal:  Mol Cell Biol       Date:  2004-01       Impact factor: 4.272

6.  Erasure of CpG methylation in Arabidopsis alters patterns of histone H3 methylation in heterochromatin.

Authors:  Muhammad Tariq; Hidetoshi Saze; Aline V Probst; Jacek Lichota; Yoshiki Habu; Jerzy Paszkowski
Journal:  Proc Natl Acad Sci U S A       Date:  2003-07-09       Impact factor: 11.205

7.  Transcriptional silencing of a transgene by RNAi in the soma of C. elegans.

Authors:  Alla Grishok; Jina L Sinskey; Phillip A Sharp
Journal:  Genes Dev       Date:  2005-03-01       Impact factor: 11.361

8.  ARGONAUTE4 is required for resistance to Pseudomonas syringae in Arabidopsis.

Authors:  Astrid Agorio; Pablo Vera
Journal:  Plant Cell       Date:  2007-11-09       Impact factor: 11.277

9.  Suppression of histone H1 genes in Arabidopsis results in heritable developmental defects and stochastic changes in DNA methylation.

Authors:  Andrzej T Wierzbicki; Andrzej Jerzmanowski
Journal:  Genetics       Date:  2004-10-16       Impact factor: 4.562

Review 10.  RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond.

Authors:  Stephane E Castel; Robert A Martienssen
Journal:  Nat Rev Genet       Date:  2013-02       Impact factor: 53.242
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