Literature DB >> 12496214

A single-copy gene encodes Kex1, a serine endoprotease of Pneumocystis jiroveci.

Geetha Kutty1, Joseph A Kovacs.   

Abstract

We have cloned and characterized the kex1 gene of Pneumocystis jiroveci. Unlike the case for Pneumocystis carinii, in which the homologous PRT-1 genes are multicopy, kex1 is a single-copy gene encoding a protein homologous to fungal serine endoproteases, which localize to the Golgi apparatus. Thus, substantial biological differences can be seen among Pneumocystis species.

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Year:  2003        PMID： 12496214      PMCID： PMC143410          DOI： 10.1128/IAI.71.1.571-574.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  23 in total

1.  Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapsone use.

Authors:  L Ma; L Borio; H Masur; J A Kovacs
Journal:  J Infect Dis       Date:  1999-12       Impact factor: 5.226

2.  Characterization of a multicopy family of genes encoding a surface-expressed serine endoprotease in rat Pneumocystis carinii.

Authors:  D A Russian; V Andrawis-Sorial; M P Goheen; J C Edman; P Vogel; R E Turner; D L Klivington; C W Angus; J A Kovacs
Journal:  Proc Assoc Am Physicians       Date:  1999 Jul-Aug

3.  Characterization of the expression site of the major surface glycoprotein of human-derived Pneumocystis carinii.

Authors:  G Kutty; L Ma; J A Kovacs
Journal:  Mol Microbiol       Date:  2001-10       Impact factor: 3.501

4.  Genetic divergence of the dihydrofolate reductase and dihydropteroate synthase genes in Pneumocystis carinii from 7 different host species.

Authors:  L Ma; H Imamichi; A Sukura; J A Kovacs
Journal:  J Infect Dis       Date:  2001-10-10       Impact factor: 5.226

5.  The KEX2 gene of Candida glabrata is required for cell surface integrity.

Authors:  O Bader; M Schaller; S Klein; J Kukula; K Haack; F Mühlschlegel; H C Korting; W Schäfer; B Hube
Journal:  Mol Microbiol       Date:  2001-09       Impact factor: 3.501

6.  Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor.

Authors:  D Julius; A Brake; L Blair; R Kunisawa; J Thorner
Journal:  Cell       Date:  1984-07       Impact factor: 41.582

7.  An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction.

Authors:  H Masur; M A Michelis; J B Greene; I Onorato; R A Stouwe; R S Holzman; G Wormser; L Brettman; M Lange; H W Murray; S Cunningham-Rundles
Journal:  N Engl J Med       Date:  1981-12-10       Impact factor: 91.245

8.  Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.

Authors:  R S Fuller; A Brake; J Thorner
Journal:  Proc Natl Acad Sci U S A       Date:  1989-03       Impact factor: 11.205

9.  Intracellular targeting and structural conservation of a prohormone-processing endoprotease.

Authors:  R S Fuller; A J Brake; J Thorner
Journal:  Science       Date:  1989-10-27       Impact factor: 47.728

Review 10.  A new name (Pneumocystis jiroveci) for Pneumocystis from humans.

Authors:  James R Stringer; Charles B Beard; Robert F Miller; Ann E Wakefield
Journal:  Emerg Infect Dis       Date:  2002-09       Impact factor: 6.883
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  17 in total

1.  Seroepidemiological study of Pneumocystis jirovecii infection in healthy infants in Chile using recombinant fragments of the P. jirovecii major surface glycoprotein.

Authors:  Kpandja Djawe; Kieran R Daly; Sergio L Vargas; M Elena Santolaya; Carolina A Ponce; Rebeca Bustamante; Judith Koch; Linda Levin; Peter D Walzer
Journal:  Int J Infect Dis       Date:  2010-12       Impact factor: 3.623

Review 2.  Pneumocystis.

Authors:  Francis Gigliotti; Andrew H Limper; Terry Wright
Journal:  Cold Spring Harb Perspect Med       Date:  2014-11-03       Impact factor: 6.915

3.  Genetic characterization of the UCS and Kex1 loci of Pneumocystis jirovecii.

Authors:  F Esteves; A Tavares; M C Costa; J Gaspar; F Antunes; O Matos
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2008-08-21       Impact factor: 3.267

4.  Serologic responses to pneumocystis proteins in HIV patients with and without Pneumocystis jirovecii pneumonia.

Authors:  Matthew R Gingo; Lorrie Lucht; Kieran R Daly; Kpandja Djawe; Frank J Palella; Alison G Abraham; Jay H Bream; Mallory D Witt; Lawrence A Kingsley; Karen A Norris; Peter D Walzer; Alison Morris
Journal:  J Acquir Immune Defic Syndr       Date:  2011-07-01       Impact factor: 3.731

Review 5.  Colonization by Pneumocystis jirovecii and its role in disease.

Authors:  Alison Morris; Karen A Norris
Journal:  Clin Microbiol Rev       Date:  2012-04       Impact factor: 26.132

6.  Characterization of a novel ADAM protease expressed by Pneumocystis carinii.

Authors:  Cassie C Kennedy; Theodore J Kottom; Andrew H Limper
Journal:  Infect Immun       Date:  2009-05-18       Impact factor: 3.441

7.  Pneumocystis colonization in immunocompetent and simian immunodeficiency virus-infected cynomolgus macaques.

Authors:  Heather M Kling; Timothy W Shipley; Sangita Patil; Alison Morris; Karen A Norris
Journal:  J Infect Dis       Date:  2009-01-01       Impact factor: 5.226

Review 8.  Pneumocystis: a novel pathogen in chronic obstructive pulmonary disease?

Authors:  Alison Morris; Frank C Sciurba; Karen A Norris
Journal:  COPD       Date:  2008-02       Impact factor: 2.409

9.  Long-term serologic responses to the Pneumocystis jirovecii major surface glycoprotein in HIV-positive individuals with and without P. jirovecii infection.

Authors:  Peter D Walzer; Kpandja Djawe; Linda Levin; Kieran R Daly; Judith Koch; Lawrence Kingsley; Mallory Witt; Elizabeth T Golub; Jay H Bream; Babafemi Taiwo; Alison Morris
Journal:  J Infect Dis       Date:  2009-05-01       Impact factor: 5.226

10.  Serum antibody levels to the Pneumocystis jirovecii major surface glycoprotein in the diagnosis of P. jirovecii pneumonia in HIV+ patients.

Authors:  Kpandja Djawe; Laurence Huang; Kieran R Daly; Linda Levin; Judy Koch; Alexandra Schwartzman; Serena Fong; Brenna Roth; Anuradha Subramanian; Katherine Grieco; Leah Jarlsberg; Peter D Walzer
Journal:  PLoS One       Date:  2010-12-09       Impact factor: 3.240
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