Literature DB >> 18716807

Genetic characterization of the UCS and Kex1 loci of Pneumocystis jirovecii.

F Esteves1, A Tavares, M C Costa, J Gaspar, F Antunes, O Matos.   

Abstract

Nucleotide variation in the Pneumocystis jirovecii upstream conserved sequence (UCS) and kexin-like serine protease (Kex1) loci was studied in pulmonary specimens from Portuguese HIV-positive patients. DNA was extracted and used for specific molecular sequence analysis. The number of UCS tandem repeats detected in 13 successfully sequenced isolates ranged from three (9 isolates, 69%) to four (4 isolates, 31%). A novel tandem repeat pattern and two novel polymorphisms were detected in the UCS region. For the Kex1 gene, the wild-type (24 isolates, 86%) was the most frequent sequence detected among the 28 sequenced isolates. Nevertheless, a nonsynonymous (1 isolate, 3%) and three synonymous (3 isolates, 11%) polymorphisms were detected and are described here for the first time.

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Year:  2008        PMID： 18716807     DOI： 10.1007/s10096-008-0596-1

Source DB:  PubMed          Journal:  Eur J Clin Microbiol Infect Dis        ISSN： 0934-9723            Impact factor:   3.267


  14 in total

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Journal:  Infect Immun       Date:  2001-02       Impact factor: 3.441

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Authors:  O Matos; B Lundgren; L Caldeira; K Mansinho; P Aguiar; M Forte; F Antunes
Journal:  Clin Microbiol Infect       Date:  2000-03       Impact factor: 8.067

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Journal:  Mol Microbiol       Date:  1999-03       Impact factor: 3.501

4.  Detection of Pneumocystis jirovecii dihydropteroate synthase polymorphisms in patients with Pneumocystis pneumonia.

Authors:  M C Costa; J Gaspar; K Mansinho; F Esteves; F Antunes; O Matos
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Review 6.  Antigenic variation in pneumocystis.

Authors:  James R Stringer
Journal:  J Eukaryot Microbiol       Date:  2007 Jan-Feb       Impact factor: 3.346

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Authors:  G Kutty; L Ma; J A Kovacs
Journal:  Mol Microbiol       Date:  2001-10       Impact factor: 3.501

8.  Unique telomeric expression site of major-surface-glycoprotein genes of Pneumocystis carinii.

Authors:  M Wada; Y Nakamura
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Journal:  Microbiology       Date:  2004-02       Impact factor: 2.777

10.  Pneumocystis jirovecii multilocus genotyping profiles in patients from Portugal and Spain.

Authors:  F Esteves; M A Montes-Cano; C de la Horra; M C Costa; E J Calderón; F Antunes; O Matos
Journal:  Clin Microbiol Infect       Date:  2008-02-02       Impact factor: 8.067
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Journal:  Sci Rep       Date:  2019-02-04       Impact factor: 4.379

4.  Development of a Gold Nanoparticle-Based Lateral-Flow Immunoassay for Pneumocystis Pneumonia Serological Diagnosis at Point-of-Care.

Authors:  Ana Luísa Tomás; Miguel P de Almeida; Fernando Cardoso; Mafalda Pinto; Eulália Pereira; Ricardo Franco; Olga Matos
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5.  Detection of anti-Pneumocystis jirovecii antibodies in human serum using a recombinant synthetic multi-epitope kexin-based antigen.

Authors:  Ana Luísa Tomás; Fernando Cardoso; Bruno de Sousa; Olga Matos
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2020-06-16       Impact factor: 3.267

Review 6.  Consensus Multilocus Sequence Typing Scheme for Pneumocystis jirovecii.

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