Literature DB >> 12480134

Serotonin regulates hippocampal glucocorticoid receptor expression via a 5-HT7 receptor.

Patricia Laplante1, Josie Diorio, Michael J Meaney.   

Abstract

Glucocorticoid receptor expression in primary hippocampal cell cultures was significantly increased with either 10 mM 8-bromo cAMP, 50 nM 5-carboxamidotryptamine (5-CT), a potent 5-HT7 receptor agonist, or 100 nM 5-HT. The effect of 5-HT or 5-CT was blocked with methiothepin or by a protein kinase A inhibitor, but not pindolol. These results suggest that the effects of 5-HT on hippocampal GR expression is mediated by a 5-HT7 receptor.

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Year:  2002        PMID： 12480134     DOI： 10.1016/s0165-3806(02)00550-3

Source DB:  PubMed          Journal:  Brain Res Dev Brain Res        ISSN： 0165-3806


  38 in total

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