Melissa A Suter1, Kjersti M Aagaard-Tillery. 1. Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
Abstract
Studies of environmental challenges, such as hazardous air pollutants, nonmutagenic toxins, diet choice, and maternal behavioral patterns, reveal changes in gene expression patterns, DNA methylation, and histone modifications that are in causal association with exogenous exposures. In this article we summarize some of the recent advances in the field of environmental epigenetics and highlight seminal studies that implicate in utero exposures as causative agents in altering not only the epigenome of the exposed gestation, but that of subsequent generations. Current studies of the effects of maternal behavior, exposure to environmental toxins, and exposure to maternal diet and an altered gestational milieu are summarized. Thieme Medical Publishers.
Studies of environmental challenges, such as hazardous air pollutants, nonmutagenic toxins, diet choice, and maternal behavioral patterns, reveal changes in gene expression patterns, DNA n class="Chemical">methylation, and histone modifications that are in causal association with exogenous exposures. In this article we summarize some of the recent advances in the field of environmental epigenetics and highlight seminal studies that implicate in utero exposures as causative agents in altering not only the epigenome of the exposed gestation, but that of subsequent generations. Current studies of the effects of maternal behavior, exposure to environmental toxins, and exposure to maternal diet and an altered gestational milieu are summarized. Thieme Medical Publishers.
Authors: M Oscarson; R A McLellan; H Gullstén; J A Agúndez; J Benítez; A Rautio; H Raunio; O Pelkonen; M Ingelman-Sundberg Journal: FEBS Lett Date: 1999-10-29 Impact factor: 4.124
Authors: F Lyko; B H Ramsahoye; H Kashevsky; M Tudor; M A Mastrangelo; T L Orr-Weaver; R Jaenisch Journal: Nat Genet Date: 1999-11 Impact factor: 38.330
Authors: B C Gladen; T D Zadorozhnaja; N Chislovska; D O Hryhorczuk; M C Kennicutt; R E Little Journal: Hum Exp Toxicol Date: 2000-11 Impact factor: 2.903
Authors: Bastiaan T Heijmans; Elmar W Tobi; Aryeh D Stein; Hein Putter; Gerard J Blauw; Ezra S Susser; P Eline Slagboom; L H Lumey Journal: Proc Natl Acad Sci U S A Date: 2008-10-27 Impact factor: 11.205
Authors: Melissa Suter; Philip Bocock; Lori Showalter; Min Hu; Cynthia Shope; Robert McKnight; Kevin Grove; Robert Lane; Kjersti Aagaard-Tillery Journal: FASEB J Date: 2010-11-19 Impact factor: 5.191
Authors: Melissa A Suter; Haleh Sangi-Haghpeykar; Lori Showalter; Cynthia Shope; Min Hu; Kathleen Brown; Sarah Williams; R Alan Harris; Kevin L Grove; Robert H Lane; Kjersti M Aagaard Journal: Mol Endocrinol Date: 2012-09-26
Authors: Melissa Suter; Jun Ma; Alan Harris; Lauren Patterson; Kathleen A Brown; Cynthia Shope; Lori Showalter; Adi Abramovici; Kjersti M Aagaard-Tillery Journal: Epigenetics Date: 2011-11-01 Impact factor: 4.528
Authors: Caroline E Boeke; Andrea Baccarelli; Ken P Kleinman; Heather H Burris; Augusto A Litonjua; Sheryl L Rifas-Shiman; Letizia Tarantini; Matthew Gillman Journal: Epigenetics Date: 2012-03 Impact factor: 4.528
Authors: Elena Sbrana; Melissa A Suter; Adi R Abramovici; Hal K Hawkins; Joan E Moss; Lauren Patterson; Cynthia Shope; Kjersti Aagaard-Tillery Journal: Am J Obstet Gynecol Date: 2011-06-15 Impact factor: 8.661