OBJECTIVES: To examine biobehavioral responses to an acute pain event in a Cape Town, South Africa, cohort consisting of 28 Cape Colored (mixed ancestry) newborns (n = 14) heavily exposed to alcohol during pregnancy (exposed), and born to abstainers (n = 14) or light (< or = 0.5 oz absolute alcohol/d) drinkers (controls). METHODS: Mothers were recruited during the third trimester of pregnancy. Newborn data were collected on postpartum day 3 in the maternity obstetrical unit where the infant had been delivered. Heavy prenatal alcohol exposure was defined as maternal consumption of at least 14 drinks/wk or at least 1 incident of binge drinking/mo. Acute stress-related biobehavioral markers [salivary cortisol, heart rate (HR), respiratory sinus arrhythmia (RSA), spectral measures of heart rate variability (HRV), and videotaped facial actions] were collected thrice during a heel lance blood collection (baseline, lance, and recovery). After a feeding and nap, newborns were administered an abbreviated Brazelton Neonatal Behavioral Assessment Scale. RESULTS: There were no between-group differences in maternal age, marital status, parity, gravidity, depression, anxiety, pregnancy smoking, maternal education, or infant gestational age at birth (all ps > 0.15). In both groups, HR increased with the heel lance and decreased during the postlance period. The alcohol-exposed group had lower mean HR than controls throughout, and showed no change in RSA over time. Cortisol levels showed no change over time in controls but decreased over time in exposed infants. Although facial action analyses revealed no group differences in response to the heel lance, behavioral responses assessed on the Brazelton Neonatal Scale showed less arousal in the exposed group. CONCLUSIONS: Both cardiac autonomic and hypothalamic-pituitary-adrenal stress reactivity measures suggest a blunted response to an acute noxious event in alcohol-exposed newborns. This is supported by results on the Brazelton Neonatal Scale indicating reduced behavioral arousal in the exposed group. To our knowledge, these data provide the first biobehavioral examination of early pain reactivity in alcohol-exposed newborns and have important implications for understanding neuro-/biobehavioral effects of prenatal alcohol exposure in the newborn period.
OBJECTIVES: To examine biobehavioral responses to an acute pain event in a Cape Town, South Africa, cohort consisting of 28 Cape Colored (mixed ancestry) newborns (n = 14) heavily exposed to alcohol during pregnancy (exposed), and born to abstainers (n = 14) or light (< or = 0.5 oz absolute alcohol/d) drinkers (controls). METHODS: Mothers were recruited during the third trimester of pregnancy. Newborn data were collected on postpartum day 3 in the maternity obstetrical unit where the infant had been delivered. Heavy prenatal alcohol exposure was defined as maternal consumption of at least 14 drinks/wk or at least 1 incident of binge drinking/mo. Acute stress-related biobehavioral markers [salivary cortisol, heart rate (HR), respiratory sinus arrhythmia (RSA), spectral measures of heart rate variability (HRV), and videotaped facial actions] were collected thrice during a heel lance blood collection (baseline, lance, and recovery). After a feeding and nap, newborns were administered an abbreviated Brazelton Neonatal Behavioral Assessment Scale. RESULTS: There were no between-group differences in maternal age, marital status, parity, gravidity, depression, anxiety, pregnancy smoking, maternal education, or infant gestational age at birth (all ps > 0.15). In both groups, HR increased with the heel lance and decreased during the postlance period. The alcohol-exposed group had lower mean HR than controls throughout, and showed no change in RSA over time. Cortisol levels showed no change over time in controls but decreased over time in exposed infants. Although facial action analyses revealed no group differences in response to the heel lance, behavioral responses assessed on the Brazelton Neonatal Scale showed less arousal in the exposed group. CONCLUSIONS: Both cardiac autonomic and hypothalamic-pituitary-adrenal stress reactivity measures suggest a blunted response to an acute noxious event in alcohol-exposed newborns. This is supported by results on the Brazelton Neonatal Scale indicating reduced behavioral arousal in the exposed group. To our knowledge, these data provide the first biobehavioral examination of early pain reactivity in alcohol-exposed newborns and have important implications for understanding neuro-/biobehavioral effects of prenatal alcohol exposure in the newborn period.
Authors: Kathryn L Hamilton; Andrew C Harris; Jonathan C Gewirtz; Sheldon B Sparber; Lisa M Schrott Journal: Neurotoxicol Teratol Date: 2005 Jan-Feb Impact factor: 3.763
Authors: Tim F Oberlander; Ruth Eckstein Grunau; Colleen Fitzgerald; Michael Papsdorf; Dan Rurak; Wayne Riggs Journal: Pediatrics Date: 2005-02 Impact factor: 7.124
Authors: Osman S Ipsiroglu; Katarina Wind; Yi-Hsuan Amy Hung; Mai Berger; Forson Chan; Wayne Yu; Sylvia Stockler; Joanne Weinberg Journal: Sleep Med Date: 2018-10-25 Impact factor: 3.492
Authors: John I Glendinning; Joyce Tang; Ana Paula Morales Allende; Bruce P Bryant; Lisa Youngentob; Steven L Youngentob Journal: J Neurophysiol Date: 2017-05-10 Impact factor: 2.714
Authors: Joseph F Hagan; Tatiana Balachova; Jacquelyn Bertrand; Ira Chasnoff; Elizabeth Dang; Daniel Fernandez-Baca; Julie Kable; Barry Kosofsky; Yasmin N Senturias; Natasha Singh; Mark Sloane; Carol Weitzman; Jennifer Zubler Journal: Pediatrics Date: 2016-10 Impact factor: 7.124
Authors: Kevin K Caldwell; Elizabeth R Solomon; Jane J W Smoake; Chrys D Djatche de Kamgaing; Andrea M Allan Journal: Neurobiol Learn Mem Date: 2018-10-12 Impact factor: 2.877
Authors: Kirsten A Donald; J P Fouche; Annerine Roos; Nastassja Koen; Fleur M Howells; Edward P Riley; Roger P Woods; Heather J Zar; Katherine L Narr; Dan J Stein Journal: Metab Brain Dis Date: 2015-11-29 Impact factor: 3.584