| Literature DB >> 12471494 |
E D Jarvis1, V A Smith, K Wada, M V Rivas, M McElroy, T V Smulders, P Carninci, Y Hayashizaki, F Dietrich, X Wu, P McConnell, J Yu, P P Wang, A J Hartemink, S Lin.
Abstract
Biological systems by default involve complex components with complex relationships. To decipher how biological systems work, we assume that one needs to integrate information over multiple levels of complexity. The songbird vocal communication system is ideal for such integration due to many years of ethological investigation and a discreet dedicated brain network. Here we announce the beginnings of a songbird brain integrative project that involves high-throughput, molecular, anatomical, electrophysiological and behavioral levels of analysis. We first formed a rationale for inclusion of specific biological levels of analysis, then developed high-throughput molecular technologies on songbird brains, developed technologies for combined analysis of electrophysiological activity and gene regulation in awake behaving animals, and developed bioinformatic tools that predict causal interactions within and between biological levels of organization. This integrative brain project is fitting for the interdisciplinary approaches taken in the current songbird issue of the Journal of Comparative Physiology A and is expected to be conducive to deciphering how brains generate and perceive complex behaviors.Mesh：
Substances：
Year: 2002 PMID： 12471494 PMCID： PMC2509580 DOI： 10.1007/s00359-002-0358-y
Source DB: PubMed Journal: J Comp Physiol A Neuroethol Sens Neural Behav Physiol ISSN： 0340-7594 Impact factor: 1.836