Magnetic resonance imaging to identify the high-risk plaque.

Atherosclerotic plaque stability depends on 3 factors: (1) lipid core, (2) fibrous cap and its thickness, and (3) inflammation within the cap. Magnetic resonance imaging (MRI) is a noninvasive technique that can provide information on these plaque components using a variety of pulse sequences. Assessment of plaque volume and tissue components and the efficacy of lipid-lowering therapy has been performed in human aorta and carotid arteries. Imaging the coronary wall for plaque burden is a novel application of MRI. Newer approaches also include intravascular and transesophageal MRI techniques. Several emerging MR contrast agents being tested in animal models hold promise for targeted imaging of plaque. MRI is a powerful noninvasive imaging tool with high spatial resolution that continues to prove its value in determining atherosclerotic plaque volume and tissue components.