Xiao-Feng Sun1, Jun Wang2, Xiao-Li Wu2, Hui-Ying Xu2, Ying-Qi Xing3, Fang Yang4. 1. Department of Ultrasound, The First Affiliated Hospital of Jilin University, 71# Xinming Street, 130021, Changchun, China. 843276182@qq.com. 2. Department of Ultrasound, The First Affiliated Hospital of Jilin University, 71# Xinming Street, 130021, Changchun, China. 3. Department of Neurology, The First Affiliated Hospital of Jilin University, 130021, Changchun, China. 4. International Health Promotion Center, The First Affiliated Hospital of Jilin University, 130021, Changchun, China.
Abstract
PURPOSE: The aim of this study is to determine the stability of carotid atherosclerotic plaque (CAP) using contrast-enhanced ultrasound (CEUS). METHODS: CEUS images of 93 patients were evaluated to observe new vessels within CAPs. Microembolic signals (MES) were detected using transcranial Doppler (TCD). Thirty-four patients with hyperechoic plaques were evaluated as the control group. RESULTS: Eighty percent (75/93) of plaques showed contrast enhancement on CEUS, including 50.7% (38/75) of hypoechoic plaques and 49.3% (37/75) of mixed echoic plaques. No plaques in the control group showed enhancement on CEUS. With TCD, 35.5% (33/93) of patients were positive for MES. Plaques with grade 2 or 3 enhancement on CEUS had a higher positive rate for MES. Forty-one patients with grade 2 or 3 enhancement on CEUS presented with fresh infarctions confirmed by computed tomography (CT) and magnetic resonance imaging (MRI). CONCLUSIONS: In conclusion, grade 2 or 3 contrast enhancement observed on CEUS indicated vulnerable plaques.
PURPOSE: The aim of this study is to determine the stability of carotid atherosclerotic plaque (CAP) using contrast-enhanced ultrasound (CEUS). METHODS: CEUS images of 93 patients were evaluated to observe new vessels within CAPs. Microembolic signals (MES) were detected using transcranial Doppler (TCD). Thirty-four patients with hyperechoic plaques were evaluated as the control group. RESULTS: Eighty percent (75/93) of plaques showed contrast enhancement on CEUS, including 50.7% (38/75) of hypoechoic plaques and 49.3% (37/75) of mixed echoic plaques. No plaques in the control group showed enhancement on CEUS. With TCD, 35.5% (33/93) of patients were positive for MES. Plaques with grade 2 or 3 enhancement on CEUS had a higher positive rate for MES. Forty-one patients with grade 2 or 3 enhancement on CEUS presented with fresh infarctions confirmed by computed tomography (CT) and magnetic resonance imaging (MRI). CONCLUSIONS: In conclusion, grade 2 or 3 contrast enhancement observed on CEUS indicated vulnerable plaques.
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