Literature DB >> 12459027

Synthesis and antimycobacterial activity of pyrazine and quinoxaline derivatives.

Lainne E Seitz1, William J Suling, Robert C Reynolds.   

Abstract

A series of pyrazine and quinoxaline derivatives have been synthesized, and their activity against M. tuberculosis (Mtb) and Mycobacterium avium (MAC) are reported. The 4-acetoxybenzyl ester of pyrazinoic acid and 4'-acetoxybenzyl 2-quinoxalinecarboxylate showed excellent activity against Mtb (MIC ranges of less than 1-6.25 microg/mL) but only modest activity against MAC (MICs of 4-32 microg/mL).

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12459027     DOI： 10.1021/jm020310n

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  32 in total

1.  6a-Nitro-6-(2,2,7,7-tetra-methyl-tetra-hydro-3aH-bis-[1,3]dioxolo[4,5-b:4',5'-d]pyran-5-yl)-6a,6b,7,8,9,11a-hexa-hydro-6H-spiro-[chromeno[3,4-a]pyrrolizine-11,11'-indeno-[1,2-b]quinoxaline].

Authors:  T Anuradha; J Naga Siva Rao; P R Seshadri; R Raghunathan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-12-14

2.  The reactivity of phenancyl bromide under β-cyclodextrin as supramolecular catalyst: a computational survey.

Authors:  Yali Wan; Xueye Wang; Na Liu
Journal:  J Mol Model       Date:  2015-05-01       Impact factor: 1.810

3.  Ammonium chloride-catalyzed green multicomponent synthesis of dihydropyrazine and tetrahydrodiazepine derivatives "on water".

Authors:  Ahmad Shaabani; Heshmatollah Sepahvand; Shima Ghasemi
Journal:  Mol Divers       Date:  2018-11-21       Impact factor: 2.943

4.  Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Authors:  Xiaokai Li; Nina Liu; Huaning Zhang; Susan E Knudson; Richard A Slayden; Peter J Tonge
Journal:  Bioorg Med Chem Lett       Date:  2010-08-21       Impact factor: 2.823

5.  Scope and mechanistic study of the ruthenium-catalyzed ortho-C-H bond activation and cyclization reactions of arylamines with terminal alkynes.

Authors:  Chae S Yi; Sang Young Yun
Journal:  J Am Chem Soc       Date:  2005-12-07       Impact factor: 15.419

6.  Activities of Quinoxaline, Nitroquinoxaline, and [1,2,4]Triazolo[4,3-a]quinoxaline Analogs of MMV007204 against Schistosoma mansoni.

Authors:  Stefan L Debbert; Mikaela J Hintz; Christian J Bell; Kenya R Earl; Grant E Forsythe; Cécile Häberli; Jennifer Keiser
Journal:  Antimicrob Agents Chemother       Date:  2021-02-17       Impact factor: 5.191

7.  2,3-Bis(4-ethoxy-phen-yl)quinoxaline.

Authors:  Ping-Ping Ye; Cai-Li Zhang; Zhi-Qiang Du
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-12-12

8.  Pyrazino[2,3-b]indolizine-10-carbonitrile.

Authors:  Anita Stefańska; Dorota Zarzeczańska; Tadeusz Ossowski; Artur Sikorski
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-03-14

9.  1,3,5-Tris(6-chloro-pyrazin-2-yl-oxy)benzene.

Authors:  Yan Li; Jian-Wu Wang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2007-12-06

10.  Highly efficient synthesis of quinoxaline derivatives from 1,2-benzenediamine and α-aminoxylated 1,3-dicarbonyl compounds.

Authors:  Jianwei Yan; Yanhong Xu; Fangfang Zhuang; Jie Tian; Guisheng Zhang
Journal:  Mol Divers       Date:  2016-01-21       Impact factor: 2.943
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.