Literature DB >> 24526984

6a-Nitro-6-(2,2,7,7-tetra-methyl-tetra-hydro-3aH-bis-[1,3]dioxolo[4,5-b:4',5'-d]pyran-5-yl)-6a,6b,7,8,9,11a-hexa-hydro-6H-spiro-[chromeno[3,4-a]pyrrolizine-11,11'-indeno-[1,2-b]quinoxaline].

T Anuradha1, J Naga Siva Rao2, P R Seshadri1, R Raghunathan2.   

Abstract

In the title compound, C39H38N4O8, the quinoxaline and indene subunits are essentially planar, with maximum deviations of 0.071 (2) and 0.009 (2) Å, respectively. The indeno-quinoxaline system forms a dihedral angle of 72.81 (3)° with the chromenopyrrolizine system. The two dioxolane rings, as well as the pyran ring of the chromeno group and the terminal pyrrolizine, each adopt an envelope conformation with O and C as flap atoms. The central pyrrolizine ring adopts a twisted conformation. Intra-molecular C-H⋯O and C-H⋯N hydrogen bonds occur. The crystal structure exhibits C-H⋯O hydrogen bonds, and is further stablized by C-H⋯π inter-actions, forming a two-dimensional network along the bc plane.

Entities:  

Year:  2013        PMID: 24526984      PMCID: PMC3914082          DOI: 10.1107/S1600536813032467

Source DB:  PubMed          Journal:  Acta Crystallogr Sect E Struct Rep Online        ISSN: 1600-5368


  5 in total

1.  Two new brominated tyrosine derivatives from the sponge Druinella (= Psammaplysilla) purpurea.

Authors:  D M James; H B Kunze; D J Faulkner
Journal:  J Nat Prod       Date:  1991 Jul-Aug       Impact factor: 4.050

2.  A short history of SHELX.

Authors:  George M Sheldrick
Journal:  Acta Crystallogr A       Date:  2007-12-21       Impact factor: 2.290

3.  Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: the synthesis and biological activities of RPR127963 an orally bioavailable inhibitor.

Authors:  Wei He; Michael R Myers; Barbara Hanney; Alfred P Spada; Glenda Bilder; Helen Galzcinski; Dilip Amin; Saul Needle; Ken Page; Zaid Jayyosi; Mark H Perrone
Journal:  Bioorg Med Chem Lett       Date:  2003-09-15       Impact factor: 2.823

4.  Synthesis and antimycobacterial activity of pyrazine and quinoxaline derivatives.

Authors:  Lainne E Seitz; William J Suling; Robert C Reynolds
Journal:  J Med Chem       Date:  2002-12-05       Impact factor: 7.446

5.  Structure validation in chemical crystallography.

Authors:  Anthony L Spek
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2009-01-20
  5 in total

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