Literature DB >> 12444649

Chlorotrimethylsilane: a suitable reagent for the synthesis of chlorohydrin esters.

Jordi Eras1, Jonh Jairo Méndez, Mercè Balcells, Ramon Canela.   

Abstract

A new methodology for obtaining chlorohydrin esters using a one-pot esterification-chlorination reaction, in which one of the reagents, chlorotrimethylsilane, acts as solvent, is described. The reaction is stereospecific and its regioselectivity depends on the number of carbons between the hydroxyl groups present in the starting material. A mechanism is proposed.

Entities:  

Year:  2002        PMID： 12444649     DOI： 10.1021/jo026020w

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  4 in total

1.  Deoxyfluorination of alcohols with 3,3-difluoro-1,2-diarylcyclopropenes.

Authors:  Lingchun Li; Chuanfa Ni; Fei Wang; Jinbo Hu
Journal:  Nat Commun       Date:  2016-11-14       Impact factor: 14.919

2.  From symmetric glycerol derivatives to dissymmetric chlorohydrins.

Authors:  Carmen Solarte; Marc Escribà; Jordi Eras; Gemma Villorbina; Ramon Canela; Mercè Balcells
Journal:  Molecules       Date:  2011-03-02       Impact factor: 4.411

Review 3.  Preparation and Uses of Chlorinated Glycerol Derivatives.

Authors:  Anna Canela-Xandri; Mercè Balcells; Gemma Villorbina; Paul Christou; Ramon Canela-Garayoa
Journal:  Molecules       Date:  2020-05-28       Impact factor: 4.411

4.  Preparation of (S)-1-Halo-2-octanols Using Ionic Liquids and Biocatalysts.

Authors:  Mireia Oromí-Farrús; Jordi Eras; Núria Sala; Mercè Torres; Ramon Canela
Journal:  Molecules       Date:  2009-10-23       Impact factor: 4.411
  4 in total

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