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Literature DB >> 12438396

The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo.

Miroslav S Sarac¹, Angus Cameron, Iris Lindberg.

Abstract

The Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage for manifestation of toxicity. We show here that the small stable furin inhibitor hexa-D-arginine amide effectively blocks PEA-induced cell lysis and is itself noncytotoxic. Administration of hexa-D-arginine to PEA-treated mice significantly improves their survival rate and also decreases circulating levels of tumor necrosis factor alpha.

Entities: Chemical

Mesh：

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Year: 2002 PMID： 12438396 PMCID： PMC133042 DOI： 10.1128/IAI.70.12.7136-7139.2002

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.609

13 in total

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39 in total

1. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo.

Authors: Miroslav S Sarac; Juan R Peinado; Stephen H Leppla; Iris Lindberg
Journal: Infect Immun Date: 2004-01 Impact factor: 3.441

2. Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases.

Authors: Gero L Becker; Yinghui Lu; Kornelia Hardes; Boris Strehlow; Christine Levesque; Iris Lindberg; Kirsten Sandvig; Udo Bakowsky; Robert Day; Wolfgang Garten; Torsten Steinmetzer
Journal: J Biol Chem Date: 2012-04-26 Impact factor: 5.157

3. On the cutting edge of proprotein convertase pharmacology: from molecular concepts to clinical applications.

Authors: Frédéric Couture; François D'Anjou; Robert Day
Journal: Biomol Concepts Date: 2011-10-01

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Authors: Mohamed Rholam; Christine Fahy
Journal: Cell Mol Life Sci Date: 2009-03-20 Impact factor: 9.261

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Authors: Albert G Remacle; Sergey A Shiryaev; Eok-Soo Oh; Piotr Cieplak; Anupama Srinivasan; Ge Wei; Robert C Liddington; Boris I Ratnikov; Amelie Parent; Roxane Desjardins; Robert Day; Jeffrey W Smith; Michal Lebl; Alex Y Strongin
Journal: J Biol Chem Date: 2008-05-27 Impact factor: 5.157