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Literature DB >> 10087614

Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis.

S S Molloy¹, E D Anderson, F Jean, G Thomas.

Abstract

Furin is a secretory pathway endoprotease that catalyses the maturation of a strikingly diverse group of proprotein substrates, ranging from growth factors and receptors to pathogen proteins, in multiple compartments within the trans-Golgi network (TGN)/endosomal system. This review focuses on recent developments in the biochemistry and cell biology of the endoprotease, including the mechanism of TGN localization, phosphorylation-dependent regulation of protein traffic, and novel insights into early embryogenesis, extracellular matrix formation and pathogen virulence.

Entities: Gene

Mesh：

Substances：
Subtilisins
Furin

Year: 1999 PMID： 10087614 DOI： 10.1016/s0962-8924(98)01382-8

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

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Cited

133 in total

1. An acidic cluster in the cytosolic domain of human cytomegalovirus glycoprotein B is a signal for endocytosis from the plasma membrane.

Authors: S Tugizov; E Maidji; J Xiao; L Pereira
Journal: J Virol Date: 1999-10 Impact factor: 5.103

6. The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like isoform.

Authors: V V Faundez; R B Kelly
Journal: Mol Biol Cell Date: 2000-08 Impact factor: 4.138

Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis.

1. An acidic cluster in the cytosolic domain of human cytomegalovirus glycoprotein B is a signal for endocytosis from the plasma membrane.

Review 2. Regulation of neuronal function by protein trafficking: a role for the endosomal pathway.

3. A protein-based therapeutic for human cytomegalovirus infection.

4. 'Shed' furin: mapping of the cleavage determinants and identification of its C-terminus.

5. Analysis of endoplasmic reticulum trafficking signals by combinatorial screening in mammalian cells.

6. The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like isoform.

Review 7. Structure--function relationships in HIV-1 Nef.

Review 8. Directed egress of animal viruses promotes cell-to-cell spread.

9. Lysosomal hydrolase mannose 6-phosphate uncovering enzyme resides in the trans-Golgi network.

10. PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic.