Literature DB >> 12437318

Replacing the nucleobases in DNA with designer molecules.

Eric T Kool1.   

Abstract

DNA is not only a carrier of genetic information, but it is also a versatile supramolecular scaffold, arranging smaller organic structures into predesigned geometries. Herein are discussed molecular strategies in which the natural DNA bases on the sugar-phosphate backbone are replaced by other molecules. Some of the base replacements under study include fluorophores, ligands for metals, helix stabilizers, and DNA base shape mimics.

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Year:  2002        PMID： 12437318     DOI： 10.1021/ar000183u

Source DB:  PubMed          Journal:  Acc Chem Res        ISSN： 0001-4842            Impact factor:   22.384


  61 in total

1.  Effect of lesions on the dynamics of DNA on the picosecond and nanosecond timescales using a polarity sensitive probe.

Authors:  Mark M Somoza; Daniele Andreatta; Catherine J Murphy; Robert S Coleman; Mark A Berg
Journal:  Nucleic Acids Res       Date:  2004-05-06       Impact factor: 16.971

2.  Reversible bond formation enables the replication and amplification of a crosslinking salen complex as an orthogonal base pair.

Authors:  Corinna Kaul; Markus Müller; Mirko Wagner; Sabine Schneider; Thomas Carell
Journal:  Nat Chem       Date:  2011-08-28       Impact factor: 24.427

3.  Synthesis of 8-Heteroaryl-2'-deoxyguanosine Derivatives.

Authors:  Gerard Hobley; Vladimir Gubala; María Del C Rivera-Sánchez; José M Rivera
Journal:  Synlett       Date:  2008-06-01       Impact factor: 2.454

4.  Probing the interaction of archaeal DNA polymerases with deaminated bases using X-ray crystallography and non-hydrogen bonding isosteric base analogues.

Authors:  Tom Killelea; Samantak Ghosh; Samuel S Tan; Pauline Heslop; Susan J Firbank; Eric T Kool; Bernard A Connolly
Journal:  Biochemistry       Date:  2010-07-13       Impact factor: 3.162

5.  Changes in DNA bending induced by restricting nucleotide ring pucker studied by weak alignment NMR spectroscopy.

Authors:  Zhengrong Wu; Melissa Maderia; Joseph J Barchi; Victor E Marquez; Ad Bax
Journal:  Proc Natl Acad Sci U S A       Date:  2004-12-23       Impact factor: 11.205

6.  Polymerase amplification, cloning, and gene expression of benzo-homologous "yDNA" base pairs.

Authors:  Jijumon Chelliserrykattil; Haige Lu; Alex H F Lee; Eric T Kool
Journal:  Chembiochem       Date:  2008-12-15       Impact factor: 3.164

Review 7.  Toward an Expanded Genome: Structural and Computational Characterization of an Artificially Expanded Genetic Information System.

Authors:  Nigel G J Richards; Millie M Georgiadis
Journal:  Acc Chem Res       Date:  2017-06-08       Impact factor: 22.384

8.  Evolving a polymerase for hydrophobic base analogues.

Authors:  David Loakes; José Gallego; Vitor B Pinheiro; Eric T Kool; Philipp Holliger
Journal:  J Am Chem Soc       Date:  2009-10-21       Impact factor: 15.419

9.  2-Methoxypyridine as a Thymidine Mimic in Watson-Crick Base Pairs of DNA and PNA: Synthesis, Thermal Stability, and NMR Structural Studies.

Authors:  Irina Novosjolova; Scott D Kennedy; Eriks Rozners
Journal:  Chembiochem       Date:  2017-09-26       Impact factor: 3.164

10.  Structural studies of RNA/DNA polypurine tracts.

Authors:  Megan E Fitzgerald; Alexander C Drohat
Journal:  Chem Biol       Date:  2008-03
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