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Literature DB >> 12435706

AcrAB Efflux System: Expression and Contribution to Fluoroquinolone Resistance in Klebsiella spp.

Annarita Mazzariol¹, Jessica Zuliani, Giuseppe Cornaglia, Gian Maria Rossolini, Roberta Fontana.

Abstract

Seven Klebsiella pneumoniae and four Klebsiella oxytoca clinical isolates with different levels of resistance to ciprofloxacin were studied. Mutations in the topoisomerase genes were found in almost all strains, but the contribution of a multidrug efflux system homologous to AcrAB in Escherichia coli was also observed. Overexpression of this efflux system was demonstrated by immunoblotting with antibodies against E. coli AcrA.

Entities: Chemical Disease Species

Mesh：

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Year: 2002 PMID： 12435706 PMCID： PMC132751 DOI： 10.1128/AAC.46.12.3984-3986.2002

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

13 in total

1. Prevalence of gyrA, gyrB, parC, and parE mutations in clinical isolates of Streptococcus pneumoniae with decreased susceptibilities to different fluoroquinolones and originating from Worldwide Surveillance Studies during the 1997-1998 respiratory season.

Authors: M E Jones; D F Sahm; N Martin; S Scheuring; P Heisig; C Thornsberry; K Köhrer; F J Schmitz
Journal: Antimicrob Agents Chemother Date: 2000-02 Impact factor: 5.191

2. High-level fluoroquinolone-resistant clinical isolates of Escherichia coli overproduce multidrug efflux protein AcrA.

Authors: A Mazzariol; Y Tokue; T M Kanegawa; G Cornaglia; H Nikaido
Journal: Antimicrob Agents Chemother Date: 2000-12 Impact factor: 5.191

3. Mechanisms of quinolone resistance in clinical strains of Pseudomonas aeruginosa.

Authors: S Jalal; B Wretlind
Journal: Microb Drug Resist Date: 1998 Impact factor: 3.431

4. A comparison of methods used for measuring the accumulation of quinolones by Enterobacteriaceae, Pseudomonas aeruginosa and Staphylococcus aureus.

Authors: P G Mortimer; L J Piddock
Journal: J Antimicrob Chemother Date: 1991-11 Impact factor: 5.790

5. Phylogenetic diversity of Klebsiella pneumoniae and Klebsiella oxytoca clinical isolates revealed by randomly amplified polymorphic DNA, gyrA and parC genes sequencing and automated ribotyping.

Authors: S Brisse; J Verhoef
Journal: Int J Syst Evol Microbiol Date: 2001-05 Impact factor: 2.747

6. Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.

Authors: M J Everett; Y F Jin; V Ricci; L J Piddock
Journal: Antimicrob Agents Chemother Date: 1996-10 Impact factor: 5.191

7. AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants.

Authors: H Okusu; D Ma; H Nikaido
Journal: J Bacteriol Date: 1996-01 Impact factor: 3.490

8. Association of organic solvent tolerance and fluoroquinolone resistance in clinical isolates of Escherichia coli.

Authors: M Oethinger; W V Kern; J D Goldman; S B Levy
Journal: J Antimicrob Chemother Date: 1998-01 Impact factor: 5.790

9. AcrA is a highly asymmetric protein capable of spanning the periplasm.

Authors: H I Zgurskaya; H Nikaido
Journal: J Mol Biol Date: 1999-01-08 Impact factor: 5.469

10. gyrA mutations associated with fluoroquinolone resistance in eight species of Enterobacteriaceae.

Authors: L M Weigel; C D Steward; F C Tenover
Journal: Antimicrob Agents Chemother Date: 1998-10 Impact factor: 5.191

33 in total

1. Role of beta-lactamases and porins in resistance to ertapenem and other beta-lactams in Klebsiella pneumoniae.

Authors: George A Jacoby; Debra M Mills; Nancy Chow
Journal: Antimicrob Agents Chemother Date: 2004-08 Impact factor: 5.191

2. Genetic and molecular characterization of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae with unusually high resistance to ampicillin.

Authors: Frank S Kaczmarek; Thomas D Gootz; Fadia Dib-Hajj; Wenchi Shang; Shawn Hallowell; Melissa Cronan
Journal: Antimicrob Agents Chemother Date: 2004-05 Impact factor: 5.191

3. Endocarditis caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: emergence of resistance to ciprofloxacin and piperacillin-tazobactam during treatment despite initial susceptibility.

Authors: Oren Zimhony; Inna Chmelnitsky; Rita Bardenstein; Sorel Goland; Orly Hammer Muntz; Shiri Navon Venezia; Yehuda Carmeli
Journal: Antimicrob Agents Chemother Date: 2006-09 Impact factor: 5.191

Review 4. Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria.

Authors: Laura J V Piddock
Journal: Clin Microbiol Rev Date: 2006-04 Impact factor: 26.132

5. Prevalence and role of efflux pump activity in ciprofloxacin resistance in clinical isolates of Klebsiella pneumoniae.

Authors: S Aathithan; G L French
Journal: Eur J Clin Microbiol Infect Dis Date: 2011-02-01 Impact factor: 3.267