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Literature DB >> 12419200

Immunoglobulin genes: generating diversity with AID and UNG.

Abstract

Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase, AID. Recent studies of mice deficient for the uracil-DNA glycosylase UNG, which removes U from DNA, suggest that AID catalyses the deamination of dC to dU during antibody diversification.

Entities: Chemical Gene Species

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Year: 2002 PMID： 12419200 DOI： 10.1016/s0960-9822(02)01247-2

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

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Cited

24 in total

1. Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses.

Authors: Kazuhiko Kuwahara; Satoru Fujimura; Yoshimasa Takahashi; Naomi Nakagata; Toshitada Takemori; Shinichi Aizawa; Nobuo Sakaguchi
Journal: Proc Natl Acad Sci U S A Date: 2004-01-08 Impact factor: 11.205

2. Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias.

Authors: Zheng Xiao; Madhumita Ray; Chuancang Jiang; Alan B Clark; Igor B Rogozin; Marilyn Diaz
Journal: Mol Immunol Date: 2007-01-22 Impact factor: 4.407

Immunoglobulin genes: generating diversity with AID and UNG.

1. Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses.

2. Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias.

3. Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.

4. A high-resolution landscape of mutations in the BCL6 super-enhancer in normal human B cells.

5. Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination.

6. Novel antibody switching defects in human patients.

7. Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled.

8. RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells.

Review 9. Why does cytotoxic chemotherapy cure only some cancers?

10. Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region.