Literature DB >> 14559972

RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells.

Tomonori Eto1, Kazuo Kinoshita, Kiyotsugu Yoshikawa, Masamichi Muramatsu, Tasuku Honjo.   

Abstract

Antibody diversification by somatic hypermutation, gene conversion, and class switch recombination is completely dependent on activation-induced cytidine deaminase (AID). A recent report showing induction of DNA mutations in Escherichia coli by overexpression of AID, Apobec-1, and related members of the RNA-editing cytidine deaminase family suggested that they may directly modify deoxycytidine in DNA in mammalian cells (DNA-editing model). We therefore examined whether Apobec-1 bona fide RNA-editing enzyme could show somatic hypermutation and class switching activities in murine B lymphocytes and fibroblasts. Unlike AID, Apobec-1 was unable to induce somatic hypermutation or class switching. The results force a reevaluation of the physiological significance of the DNA deaminase activities of AID and Apobec-1 in E. coli and in vitro.

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Year:  2003        PMID： 14559972      PMCID： PMC240715          DOI： 10.1073/pnas.2135587100

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  33 in total

1.  Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing.

Authors:  Y Yang; Y Yang; H C Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1997-11-25       Impact factor: 11.205

2.  Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.

Authors:  M Muramatsu; K Kinoshita; S Fagarasan; S Yamada; Y Shinkai; T Honjo
Journal:  Cell       Date:  2000-09-01       Impact factor: 41.582

3.  Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells.

Authors:  M Muramatsu; V S Sankaranand; S Anant; M Sugai; K Kinoshita; N O Davidson; T Honjo
Journal:  J Biol Chem       Date:  1999-06-25       Impact factor: 5.157

4.  AID mutant analyses indicate requirement for class-switch-specific cofactors.

Authors:  Van-Thanh Ta; Hitoshi Nagaoka; Nadia Catalan; Anne Durandy; Alain Fischer; Kohsuke Imai; Shigeaki Nonoyama; Junko Tashiro; Masaya Ikegawa; Satomi Ito; Kazuo Kinoshita; Masamichi Muramatsu; Tasuku Honjo
Journal:  Nat Immunol       Date:  2003-08-10       Impact factor: 25.606

5.  The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay.

Authors:  Ann Chester; Angelika Somasekaram; Maria Tzimina; Adam Jarmuz; Jane Gisbourne; Raymond O'Keefe; James Scott; Naveenan Navaratnam
Journal:  EMBO J       Date:  2003-08-01       Impact factor: 11.598

6.  Alternative mRNA splicing and differential promoter utilization determine tissue-specific expression of the apolipoprotein B mRNA-editing protein (Apobec1) gene in mice. Structure and evolution of Apobec1 and related nucleoside/nucleotide deaminases.

Authors:  M Nakamuta; K Oka; J Krushkal; K Kobayashi; M Yamamoto; W H Li; L Chan
Journal:  J Biol Chem       Date:  1995-06-02       Impact factor: 5.157

7.  Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation.

Authors:  Phuong Pham; Ronda Bransteitter; John Petruska; Myron F Goodman
Journal:  Nature       Date:  2003-06-18       Impact factor: 49.962

8.  A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice.

Authors:  P Shockett; M Difilippantonio; N Hellman; D G Schatz
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-03       Impact factor: 11.205

9.  Constitutive expression of AID leads to tumorigenesis.

Authors:  Il-mi Okazaki; Hiroshi Hiai; Naoki Kakazu; Shuichi Yamada; Masamichi Muramatsu; Kazuo Kinoshita; Tasuku Honjo
Journal:  J Exp Med       Date:  2003-05-05       Impact factor: 14.307

10.  AID mediates hypermutation by deaminating single stranded DNA.

Authors:  Sarah K Dickerson; Eleonora Market; Eva Besmer; F Nina Papavasiliou
Journal:  J Exp Med       Date:  2003-05-19       Impact factor: 14.307
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  13 in total

1.  The cytidine deaminases AID and APOBEC-1 exhibit distinct functional properties in a novel yeast selectable system.

Authors:  Kristina Krause; Kenneth B Marcu; Jobst Greeve
Journal:  Mol Immunol       Date:  2005-06-15       Impact factor: 4.407

Review 2.  The dark side of activation-induced cytidine deaminase: relationship with leukemia and beyond.

Authors:  Kazuo Kinoshita; Taichiro Nonaka
Journal:  Int J Hematol       Date:  2006-04       Impact factor: 2.490

3.  APOBEC3B and AID have similar nuclear import mechanisms.

Authors:  Lela Lackey; Zachary L Demorest; Allison M Land; Judd F Hultquist; William L Brown; Reuben S Harris
Journal:  J Mol Biol       Date:  2012-03-23       Impact factor: 5.469

4.  De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination.

Authors:  Nasim A Begum; Kazuo Kinoshita; Masamichi Muramatsu; Hitoshi Nagaoka; Reiko Shinkura; Tasuku Honjo
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-18       Impact factor: 11.205

5.  The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1.

Authors:  Kefang Xie; Mark P Sowden; Geoffrey S C Dance; Andrew T Torelli; Harold C Smith; Joseph E Wedekind
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-17       Impact factor: 11.205

6.  Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1.

Authors:  Satomi Ito; Hitoshi Nagaoka; Reiko Shinkura; Nasim Begum; Masamichi Muramatsu; Mikiyo Nakata; Tasuku Honjo
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-09       Impact factor: 11.205

7.  The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination.

Authors:  Tomomitsu Doi; Lucia Kato; Satomi Ito; Reiko Shinkura; Min Wei; Hitoshi Nagaoka; Jishu Wang; Tasuku Honjo
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-06       Impact factor: 11.205

8.  Binding of AID to DNA does not correlate with mutator activity.

Authors:  Allysia J Matthews; Solomon Husain; Jayanta Chaudhuri
Journal:  J Immunol       Date:  2014-05-30       Impact factor: 5.422

9.  APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase.

Authors:  Rodolphe Suspène; Peter Sommer; Michel Henry; Stéphane Ferris; Denise Guétard; Sylvie Pochet; Ann Chester; Naveenan Navaratnam; Simon Wain-Hobson; Jean-Pierre Vartanian
Journal:  Nucleic Acids Res       Date:  2004-04-30       Impact factor: 16.971

10.  Negative regulation of activation-induced cytidine deaminase in B cells.

Authors:  Taro Muto; Il-mi Okazaki; Shuichi Yamada; Yoshimasa Tanaka; Kazuo Kinoshita; Masamichi Muramatsu; Hitoshi Nagaoka; Tasuku Honjo
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-13       Impact factor: 11.205
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