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Literature DB >> 12414729

Strand pairing by Rad54 and Rad51 is enhanced by chromatin.

Abstract

We investigated the role of chromatin in the catalysis of homologous strand pairing by Rad54 and Rad51. Rad54 is related to the ATPase subunits of chromatin-remodeling factors, whereas Rad51 is related to bacterial RecA. In the absence of superhelical tension, we found that the efficiency of strand pairing with chromatin is >100-fold higher than that with naked DNA. In addition, we observed that Rad54 and Rad51 function cooperatively in the ATP-dependent remodeling of chromatin. These findings indicate that Rad54 and Rad51 have evolved to function with chromatin, the natural substrate, rather than with naked DNA.

Entities: Chemical Gene

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Year: 2002 PMID： 12414729 PMCID： PMC187467 DOI： 10.1101/gad.1032102

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

37 in total

1. The Drosophila melanogaster DmRAD54 gene plays a crucial role in double-strand break repair after P-element excision and acts synergistically with Ku70 in the repair of X-ray damage.

Authors: R Kooistra; A Pastink; J B Zonneveld; P H Lohman; J C Eeken
Journal: Mol Cell Biol Date: 1999-09 Impact factor: 4.272

Review 2. Molecular mechanisms of DNA double strand break repair.

Authors: R Kanaar; J H Hoeijmakers; D C van Gent
Journal: Trends Cell Biol Date: 1998-12 Impact factor: 20.808

3. Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins.

Authors: G Petukhova; S Stratton; P Sung
Journal: Nature Date: 1998-05-07 Impact factor: 49.962

4. Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation.

Authors: T L Tan; J Essers; E Citterio; S M Swagemakers; J de Wit; F E Benson; J H Hoeijmakers; R Kanaar
Journal: Curr Biol Date: 1999-03-25 Impact factor: 10.834

Review 5. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae.

Authors: F Pâques; J E Haber
Journal: Microbiol Mol Biol Rev Date: 1999-06 Impact factor: 11.056

6. ACF consists of two subunits, Acf1 and ISWI, that function cooperatively in the ATP-dependent catalysis of chromatin assembly.

Authors: T Ito; M E Levenstein; D V Fyodorov; A K Kutach; R Kobayashi; J T Kadonaga
Journal: Genes Dev Date: 1999-06-15 Impact factor: 11.361

7. Heteroduplex formation by human Rad51 protein: effects of DNA end-structure, hRP-A and hRad52.

Authors: P Baumann; S C West
Journal: J Mol Biol Date: 1999-08-13 Impact factor: 5.469

8. okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis.

Authors: A Ghabrial; R P Ray; T Schüpbach
Journal: Genes Dev Date: 1998-09-01 Impact factor: 11.361

9. Stimulation by Rad52 of yeast Rad51-mediated recombination.

Authors: A Shinohara; T Ogawa
Journal: Nature Date: 1998-01-22 Impact factor: 49.962

10. Synergistic actions of Rad51 and Rad52 in recombination and DNA repair.

Authors: F E Benson; P Baumann; S C West
Journal: Nature Date: 1998-01-22 Impact factor: 49.962

65 in total

1. Dynamic properties of nucleosomes during thermal and ATP-driven mobilization.

Authors: Andrew Flaus; Tom Owen-Hughes
Journal: Mol Cell Biol Date: 2003-11 Impact factor: 4.272

2. Linking histone deacetylation with the repair of DNA breaks.

Authors: Oscar Fernandez-Capetillo; Andre Nussenzweig
Journal: Proc Natl Acad Sci U S A Date: 2004-02-02 Impact factor: 11.205

3. The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies.

Authors: Yutong Xue; Richard Gibbons; Zhijiang Yan; Dafeng Yang; Tarra L McDowell; Salvatore Sechi; Jun Qin; Sharleen Zhou; Doug Higgs; Weidong Wang
Journal: Proc Natl Acad Sci U S A Date: 2003-09-02 Impact factor: 11.205

4. Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair.

Authors: Bob Chai; Jian Huang; Bradley R Cairns; Brehon C Laurent
Journal: Genes Dev Date: 2005-07-15 Impact factor: 11.361

5. Terminal association of Rad54 protein with the Rad51-dsDNA filament.

Authors: Konstantin Kiianitsa; Jachen A Solinger; Wolf-Dietrich Heyer
Journal: Proc Natl Acad Sci U S A Date: 2006-06-19 Impact factor: 11.205

Review 6. ATP-dependent chromatin remodeling factors and DNA damage repair.

Authors: Mary Ann Osley; Toyoko Tsukuda; Jac A Nickoloff
Journal: Mutat Res Date: 2007-01-21 Impact factor: 2.433

7. An essential role of DmRad51/SpnA in DNA repair and meiotic checkpoint control.

Authors: Eric Staeva-Vieira; Siuk Yoo; Ruth Lehmann
Journal: EMBO J Date: 2003-11-03 Impact factor: 11.598

8. Genetic re-engineering of Saccharomyces cerevisiae RAD51 leads to a significant increase in the frequency of gene repair in vivo.

Authors: Li Liu; Katie K Maguire; Eric B Kmiec
Journal: Nucleic Acids Res Date: 2004-04-15 Impact factor: 16.971

Review 9. Rad54, the motor of homologous recombination.

Authors: Alexander V Mazin; Olga M Mazina; Dmitry V Bugreev; Matthew J Rossi
Journal: DNA Repair (Amst) Date: 2010-01-20

Review 10. Structure, function and regulation of CSB: a multi-talented gymnast.

Authors: Robert J Lake; Hua-Ying Fan
Journal: Mech Ageing Dev Date: 2013-02-16 Impact factor: 5.432